Molecular networking-guided investigation of the secondary metabolome of four Morus species and their in vivo neuroprotective potential for the mitigation of …

NM Hegazi, TA Mohamed, A Salama, AR Hamed… - Food & Function, 2024 - pubs.rsc.org
Alzheimer's Disease (AD) is a fatal age-related neurodegenerative condition with a
multifactorial etiology contributing to 70% of dementia globally. The search for a multi-target …

Anti-Alzheimer chemical constituents of Morus macroura Miq.: Chemical profiling, in silico and in vitro investigations

SS El-Hawary, AM Sayed, MY Issa, HS Ebrahim… - Food & Function, 2021 - pubs.rsc.org
Herein, we investigated both fruits and leaves of Morus macroura Miq. as a potential source
of bioactive compounds against Alzheimer's disease (AD). LC-HRMS-assisted chemical …

Integrated comparative metabolomics and network pharmacology approach to uncover the key active ingredients of Polygonati rhizoma and their therapeutic …

F Wang, H Chen, Y Hu, L Chen, Y Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
Alzheimer's disease (AD) has become a worldwide disease affecting human health and
resulting in a heavy economic burden on the healthcare system. Polygonati rhizoma (PR), a …

Integrated untargeted and targeted metabolomics to reveal therapeutic effect and mechanism of Alpiniae oxyphyllae fructus on Alzheimer's disease in APP/PS1 mice

S Zhou, L Liu, Y Zhang, Z Zhang, H Li, F Fan… - Frontiers in …, 2023 - frontiersin.org
Introduction: Alpiniae oxyphyllae Fructus (AOF) has been abundantly utilized for the
treatment of diarrhea, dyspepsia, kidney asthenia, and abdominal pain in China. AOF is …

Integrated brain and plasma dual-channel metabolomics to explore the treatment effects of Alpinia oxyphyllaFructus on Alzheimer's disease

Z Sun, Y Zhang, M Zhang, S Zhou, W Cheng, L Xue… - Plos one, 2023 - journals.plos.org
Alpinia oxyphylla Fructus, called Yizhi in Chinese, is the dried fruit of Alpinia oxyphylla
Miquel. It has been used in traditional Chinese medicine to treat dementia and memory …

Integrated UHPLC-Q-Orbitrap-MS/MS Method and Network Pharmacology for Exploring the Active Components and Potential Mechanisms of Neuroprotective Effect of the n …

X Wang, H Zhao, M Wu, Y Gan… - Natural Product …, 2024 - journals.sagepub.com
Background: Mume Flos is a common Qi-regulating medication used in traditional Chinese
medicine, modern study has discovered that Mume Flos and its components have …

Exploration of the pharmacological components and therapeutic mechanisms in treatment of Alzheimer's disease with Polygonati Rhizoma and its processed product …

L Xiaojuan, L Hongmei, W Zhuxin, L Xiaoqin… - Heliyon, 2024 - cell.com
Abstract Polygonati Rhizoma (PR, Huangjing in Chinese) and its processed product (PRP),
which are used in Traditional Chinese medicine (TCM) for cognitive enhancement and …

Therapeutic effect and mechanism of Anemarrhenae Rhizoma on Alzheimer's disease based on multi-platform metabolomics analyses

H Wang, JY Dai, YZ He, ZW Xia, XF Chen… - Frontiers in …, 2022 - frontiersin.org
Anemarrhenae Rhizoma (AR) has multiple pharmacological activities to prevent and treat
Alzheimer's disease (AD). However, the effect and its molecular mechanism are not …

Abelmoschus eculentus Seed Extract Exhibits In Vitro and In Vivo Anti-Alzheimer's Potential Supported by Metabolomic and Computational Investigation

HT Bakhsh, FA Mokhtar, AH Elmaidomy, HF Aly… - Plants, 2023 - mdpi.com
Abelmoschus esculentus Linn.(okra, F. Malvaceae) is a fruit widely consumed all over the
world. In our study, the anti-Alzheimer's potential of A. esculentus was evaluated. An in vitro …

Danggui Shaoyao San: comprehensive modulation of the microbiota-gut-brain axis for attenuating Alzheimer's disease-related pathology

J He, Y Jin, C He, Z Li, W Yu, J Zhou, R Luo… - Frontiers in …, 2024 - frontiersin.org
Background: Alzheimer's disease (AD), an age-associated neurodegenerative disorder,
currently lacks effective clinical therapeutics. Traditional Chinese Medicine (TCM) holds …