Breast and lung cancers are leading causes of death among patients, with their global
mortality and morbidity rates increasing. Conventional treatments often prove inadequate …

SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and
contains a high-mobility group (HMG) domain, which permits highly specific DNA binding …

BACKGROUND SOX2 is a regulator of pluripotent cellular transcription, yet it has been
recently integrated in cancer biology. The present study provides an analytic insight into the …

Sox family of transcriptional factors play essential functions in development and are
implicated in multiple clinical disorders, including cancer. Sox2 being their most prominent …

SOX2 is a transcription factor involved in multiple stages of embryonic development. In
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …

Sex-determining region Y-related high mobility group box 4 (SOX4) has been proven to
serve as a critical role in cancer development and progression. However, little is known …

Purpose Increasing evidence has shown that the transcription factor SOX4 is closely
associated with the development and progression of many malignant tumors. However, the …

The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

Cancer is a leading cause of death worldwide and around 10 million deaths in 2020 were
related to cancer. There are a number of therapeutic modalities for cancer such as …

Epithelial–mesenchymal transition (EMT) is a developmental program, which is associated
with breast cancer progression and metastasis. Here, we report that ectopic overexpression …