Systems-level immunomonitoring from acute to recovery phase of severe COVID-19
Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the
lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this …
lung, often with a sudden onset after 5–7 days of stable disease. Efforts to modulate this …
Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients
XN Zhao, Y You, XM Cui, HX Gao, GL Wang… - Signal transduction and …, 2021 - nature.com
While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are …
CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are …
A distinct innate immune signature marks progression from mild to severe COVID-19
Summary Coronavirus disease 2019 (COVID-19) manifests with a range of severities, but
immune signatures of mild and severe disease are still not fully understood. Here, we use …
immune signatures of mild and severe disease are still not fully understood. Here, we use …
Integrated immune dynamics define correlates of COVID-19 severity and antibody responses
SARS-CoV-2 causes a spectrum of COVID-19 disease, the immunological basis of which
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
remains ill defined. We analyzed 85 SARS-CoV-2-infected individuals at acute and/or …
[HTML][HTML] Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …
[HTML][HTML] Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Immune profiling of COVID-19 patients has identified numerous alterations in both innate
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
Profiling of immune dysfunction in COVID-19 patients allows early prediction of disease progression
With a rising incidence of COVID-19–associated morbidity and mortality worldwide, it is
critical to elucidate the innate and adaptive immune responses that drive disease severity …
critical to elucidate the innate and adaptive immune responses that drive disease severity …
SARS-CoV-2 infection results in immune responses in the respiratory tract and peripheral blood that suggest mechanisms of disease severity
Respiratory tract infection with SARS-CoV-2 results in varying immunopathology underlying
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …
COVID-19. We examine cellular, humoral and cytokine responses covering 382 immune …
[HTML][HTML] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …
manifestations have largely been studied in circulation. Here, we examined the relationship …
[HTML][HTML] Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19
JT Sims, V Krishnan, CY Chang, SM Engle… - Journal of Allergy and …, 2021 - Elsevier
Background Physicians treating patients with coronavirus disease 2019 (COVID-19)
increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a …
increasingly believe that the hyperinflammatory acute stage of COVID-19 results in a …