Traumatic brain injury (TBI) has come to be recognized as a risk factor for Alzheimer's
disease (AD), with poorly understood underlying mechanisms. We hypothesized that a …

Traumatic brain injury (TBI) has been discussed as a risk factor for Alzheimer's disease (AD)
due to its association with dementia risk and earlier cognitive symptom onset. However, the …

Purpose Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have
emerged as independent risk factors for an earlier onset of Alzheimer's disease (AD) …

Background and Objectives Traumatic brain injury (TBI) has been promoted as a risk factor
for Alzheimer disease (AD). There is evidence of elevated β-amyloid (Aβ) and tau, the …

Purpose Traumatic brain injury (TBI) has been proposed as a risk factor for Alzheimer's
disease (AD), although the mechanisms underlying the putative association are poorly …

The misfolding and aggregation of tau protein into neurofibrillary tangles is the main
underlying hallmark of tauopathies. Most tauopathies have a sporadic origin and can be …

Traumatic brain injury (TBI) can trigger progressive neurodegeneration, with tau pathology
seen years after a single moderate-severe TBI. Identifying this type of posttraumatic …

See Vandenberghe and Schaeverbeke (doi: 10.1093/awx065) for a scientific commentary
on this article. A long-term goal of our field is to determine the sequence of pathological …

Importance National Institute on Aging–Alzheimer's Association (NIA-AA) workgroups have
proposed biological research criteria intended to identify individuals with preclinical …

Background The initiation, anatomic pattern, and extent of tau spread in traumatic brain
injury (TBI), and the mechanism by which TBI leads to long-term tau pathology, remain …