Advanced biomaterials are increasingly used for numerous medical applications from the
delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The …

Biomaterials have emerged as powerful regulators of the cellular microenvironment for drug
discovery, tissue engineering research and chemical testing. Although biomaterial-based …

In the tissue engineering research field, nanobiomaterials highlight the impact of novel
bioactive materials in both current applications and their potentials in future progress for …

The promise of cellular therapy lies in the repair of damaged organs and tissues in vivo as
well as generating tissue constructs in vitro for subsequent transplantation. Unfortunately …

Immortalized cell lines and live animal models are commonly used for cytotoxicity screening
of biomedical devices and materials. However, these assays poorly reflect human …

Biomaterials contact directly or indirectly with the human tissues, making it important to
evaluate its cytotoxicity. This evaluation can be performed by several methods, but a high …

Introduction: Organ dysfunction and failure are major health issues affecting millions of
patients, many of whom are desperate for organ transplantation. Tissue regeneration aims at …

Stem cells play increasingly prominent roles in tissue engineering and regenerative
medicine. Pluripotent embryonic stem (ES) cells theoretically allow every cell type in the …

Toxicology has long relied on animal models in a tedious approach to understanding risk of
exposure to an uncharacterized molecule. Stem cell-derived tissues can be made in high …

Biomaterials are required to act harmoniously when exposed to the body or bodily fluids.
Investigating cellular or in vivo phenotypic responses and protein adsorption to the material …