Nrf2: INrf2 (Keap1) are cellular sensors of chemical-and radiation-induced oxidative and
electrophilic stress. Nrf2 is a nuclear transcription factor that controls the expression and …

Abstract Nrf2: INrf2 (Keap1) are cellular sensors of oxidative and electrophilic stress. Nrf2 is
a nuclear factor that controls the expression and coordinated induction of a battery of genes …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

Nrf2: INrf2 acts as a sensor for oxidative/electrophilic stress. INrf2 serves as an adaptor to
link Nrf2 to the ubiquitin ligase Cul3–Rbx1 complex that ubiquitinate and degrade Nrf2 …

INrf2: Nrf2 are sensors of chemical/radiation stress. Nrf2 dissociates from INrf2 in response
to a stress and translocates in the nucleus. This leads to induction of a battery of antioxidant …

The transcription factor Nrf2 regulates the basal and inducible expression of numerous
detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and …

Abstract Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against
environmental stresses. Nrf2 induces the expression of detoxification and antioxidant …

The KEAP1-NRF2 system plays a central role in cytoprotection. NRF2 is stabilized in
response to electrophiles and activates transcription of antioxidant genes. Although robust …

Since eukaryotic cells constantly encounter various environmental insults, they have
evolved defense mechanisms to cope with toxicant-and carcinogen-induced oxidative stress …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …