Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are
pivotal regulators of extracellular matrix (ECM) composition and could, due to their dynamic …

Objective: Remodeling of extracellular matrix (ECM) is considered to contribute to
progression of left ventricular (LV) remodeling and matrix metalloproteinases (MMPs) play …

Opinion statement Milestones in the progression to heart failure following myocardial
infarction (MI) are changes in left ventricular (LV) geometry and function, termed post-MI …

BACKGROUND: Extracellular matrix remodeling is thought to play an important role in the
progression of heart failure (HF). Matrix metalloproteinases (MMPs) and tissue inhibitors of …

BACKGROUND: Matrix metalloproteinases (MMPs) can alter myocardial extracellular matrix
and thereby contribute to adverse ventricular remodeling in progressive heart failure (HF) …

In chronic congestive heart failure, an illness affecting more than 4 million Americans, there
is extensive myocardial extracellular matrix (ECM) remodeling. Failing human ventricular …

Cardiovascular disease poses a major health care burden in the Western world. Following
myocardial injuries, ventricular remodelling and dysfunction ensue, which can eventually …

Aims The left ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) can appear
similar in paediatric and adult patients. However, the aetiology of paediatric DCM is usually …

Myocardial fibrosis due to maladaptive extracellular matrix remodeling contributes to
dysfunction of the failing heart. Further elucidation of the mechanism by which myocardial …

Regulation of the extracellular matrix (ECM) is an important therapeutic target that can
potentially attenuate the adverse ventricular remodeling seen in the progression of heart …