BST2 is an interferon-inducible antiviral host protein antagonized by HIV-1 Vpu that entraps
nascent HIV-1 virions on the cell surface. Unexpectedly, we find that HIV-1 lacking Nef can …

Pathogenic simian–human immunodeficiency viruses (SHIV) contain HIV-1 Vpu and SIV
Nef, both shown to counteract BST-2 (HM1. 24; CD317; tetherin) inhibition of virus release in …

Binding of anti-HIV antibodies (Abs) to envelope (Env) glycoproteins on infected cells can
mark them for elimination via antibody-dependent cell-mediated cytotoxicity (ADCC). BST2 …

Tetherin, also known as BST2, CD317 or HM1. 24, was recently identified as an interferon-
inducible host–cell factor that interferes with the detachment of virus particles from infected …

Human immunodeficiency virus type 1 (HIV-1) groups M, N, O, and P are the result of
independent zoonotic transmissions of simian immunodeficiency viruses (SIVs) infecting …

The HIV-1 protein Vpu counteracts the antiviral activity of the innate restriction factor BST-
2/tetherin by a mechanism that partly depends on its interaction with β-TrCP, a substrate …

The role of accessory proteins during cell-to-cell transmission of HIV-1 has not been
explicitly defined. In part, this is related to difficulties in measuring virus replication in cell …

ABSTRACT BST2/tetherin is a type I interferon (IFN-I)-stimulated host factor that restricts the
release of HIV-1 by entrapping budding virions at the cell surface. This membrane …

Background Vpu is a multifunctional accessory protein that enhances the release of HIV-1
by counteracting the entrapment of nascent virions on infected cell surface mediated by …

Although Nef is the viral gene product used by most simian immunodeficiency viruses to
overcome restriction by tetherin, this activity was acquired by the Vpu protein of HIV-1 group …