Pharmacogenetics studies the relationship between a person's individual genetic
characteristics and the human body's response to the action of various drugs, particularly the …

This survey of literature highlights the issues of pharmacogenetics and pharmacogenomics,
the nomenclature of polymorphisms and the major clinically significant polymorphisms for …

Pharmacogenetics was born within the field of anesthesiology in the mid-1950s with the first
observations that genetic factors might affect the response to various pharmacological …

Pharmacogenetics, the study of the variability in drug response due to genetic variability,
was born in the mid-1950s with the first observations that genetic factors may affect the …

General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia
induced by drugs including opioids, hypnotic-sedative agents, muscle relaxants and …

'If it were not for the great variability among individuals, medicine might as well be a science
and not an art.'Sir William Osler's observations in 189260 reflect a perception of medicine …

The ultimate goal of pharmacogenetics research is to help doctors tailor doses of medicines
to a person's unique genetic make-up, making medicines safer and more effective for …

The incidence and potential for serious adverse drug reactions (SADRs) in anesthesia are
high due to the narrow therapeutic indices of anesthetic and analgesic drugs and high …

Relevance. It is known that in children the frequency of perioperative critical events due to
the introduction of drugs is more than 5%. For example fentanyl, which is used as an adjunct …

The differences in response of a patient to total intravenous anesthesia could, at least in
part, be explained by genetically determined differences in anesthetic metabolism and …