Hfq‐dependent, co‐ordinate control of cyclic diguanylate synthesis and catabolism in the plague pathogen Yersinia pestis

LE Bellows, BJ Koestler, SM Karaba… - Molecular …, 2012 - Wiley Online Library
Y ersinia pestis, the cause of the disease plague, forms biofilms to enhance flea‐to‐mammal
transmission. Biofilm formation is dependent on exopolysaccharide synthesis and is …

The hmsT 3′ untranslated region mediates c‐di‐GMP metabolism and biofilm formation in Yersinia pestis

H Zhu, XJ Mao, XP Guo, YC Sun - Molecular Microbiology, 2016 - Wiley Online Library
Yersinia pestis, the cause of plague, forms a biofilm in the proventriculus of its flea vector to
enhance transmission. Biofilm formation in Y. pestis is regulated by the intracellular levels of …

CsrA Enhances Cyclic-di-GMP Biosynthesis and Yersinia pestis Biofilm Blockage of the Flea Foregut by Alleviating Hfq-Dependent Repression of the hmsT mRNA

AR Silva-Rohwer, K Held, J Sagawa, NL Fernandez… - MBio, 2021 - Am Soc Microbiol
Plague-causing Yersinia pestis is transmitted through regurgitation when it forms a biofilm-
mediated blockage in the foregut of its flea vector. This biofilm is composed of an …

HmsC, a periplasmic protein, controls biofilm formation via repression of HmsD, a diguanylate cyclase in Yersinia pestis

GX Ren, HQ Yan, H Zhu, XP Guo… - Environmental …, 2014 - Wiley Online Library
Y ersinia pestis, the cause of plague, forms a biofilm in the foregut of its flea vector to
enhance transmission. Biofilm formation in Y. pestis is controlled by the intracellular levels of …

HmsB enhances biofilm formation in Yersinia pestis

N Fang, S Qu, H Yang, H Fang, L Liu, Y Zhang… - Frontiers in …, 2014 - frontiersin.org
The hmsHFRS operon is responsible for biosynthesis and translocation of biofilm matrix
exopolysaccharide. Yersinia pestis expresses the two sole diguanylate cyclases HmsT and …

Differential regulation of the hmsCDE operon in Yersinia pestis and Yersinia pseudotuberculosis by the Rcs phosphorelay system

XP Guo, GX Ren, H Zhu, XJ Mao, YC Sun - Scientific reports, 2015 - nature.com
Yersinia pestis, the agent of plague, forms a biofilm in its flea vector to enhance
transmission. Y. pestis biofilm development is positively regulated by hmsT and hmsD …

Systematic analysis of cyclic di‐GMP signalling enzymes and their role in biofilm formation and virulence in Yersinia pestis

AG Bobrov, O Kirillina, DA Ryjenkov… - Molecular …, 2011 - Wiley Online Library
Cyclic di‐GMP (c‐di‐GMP) is a signalling molecule that governs the transition between
planktonic and biofilm states. Previously, we showed that the diguanylate cyclase HmsT and …

Differential Control of Yersinia pestis Biofilm Formation In Vitro and in the Flea Vector by Two c-di-GMP Diguanylate Cyclases

YC Sun, A Koumoutsi, C Jarrett, K Lawrence… - PloS one, 2011 - journals.plos.org
Yersinia pestis forms a biofilm in the foregut of its flea vector that promotes transmission by
flea bite. As in many bacteria, biofilm formation in Y. pestis is controlled by intracellular …

The Yersinia pestis Rcs Phosphorelay Inhibits Biofilm Formation by Repressing Transcription of the Diguanylate Cyclase Gene hmsT

YC Sun, XP Guo, BJ Hinnebusch… - Journal of bacteriology, 2012 - Am Soc Microbiol
Yersinia pestis, which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a
means to enhance transmission. Biofilm development is positively regulated by hmsT …

Differential Regulation of c-di-GMP Metabolic Enzymes by Environmental Signals Modulates Biofilm Formation in Yersinia pestis

GX Ren, S Fan, XP Guo, S Chen, YC Sun - Frontiers in Microbiology, 2016 - frontiersin.org
Cyclic diguanylate (c-di-GMP) is essential for Yersinia pestis biofilm formation, which is
important for flea-borne blockage-dependent plague transmission. Two diguanylate …