Adoptive transfer of T lymphocytes is a promising treatment for a variety of malignancies but
often not feasible due to difficulties generating T cells that are reactive with the targeted …

Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to
target both hematological malignancies and solid tumors. By introducing a TCR, large …

A promising approach to adoptive transfer therapy of tumors is to reprogram autologous T
lymphocytes by TCR gene transfer of defined Ag specificity. An obstacle, however, is the …

Primary human activated T lymphocytes were genetically grafted with chimeric T cell
receptors (TCR). Three domain single chain (sc-) TCR as well as two chain (tc-) TCR gene …

TCR gene therapy using adoptive transfer of TCR gene-modified T cells is a new strategy for
treatment of cancer. One critical prerequisite for TCR gene therapy is sufficient expression of …

Adoptive transfer of genetically T-cell receptor (TCR)–modified lymphocytes has been
recently reported to cause objective cancer regression. However, a major limitation to this …

Adoptive transfer of T-cell receptor (TCR) genes has been proposed as an attractive
approach for immunotherapy in cases where the endogenous T-cell repertoire is insufficient …

Expression of native transgenic T cell receptors in recipient human T cells is often
insufficient to achieve highly reactive T cell bulks. Here we show that codon modification of …

T cell receptor (TCR) gene transfer is a convenient method to produce antigen‐specific T
cells for adoptive therapy. However, the expression of two TCR in T cells could impair their …

A recent phase 1 trial has demonstrated that the generation of tumor-reactive T lymphocytes
by transfer of specific T-cell receptor (TCR) genes into autologous lymphocytes is feasible …