[图书][B] An insight into the metabolism of New Psychoactive Substances: Structural elucidation of urinary metabolites of synthetic cannabinoids and fentanyl analogues …

J Wallgren - 2020 - books.google.com
New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances
across different drug groups. Many of these substances were originally developed for …

Advances in urinary biomarker research of synthetic cannabinoids

Z Wang, EYQ Leow, HY Moy, ECY Chan - Advances in clinical chemistry, 2023 - Elsevier
New psychoactive substances (NPS) are chemical compounds designed to mimic the action
of existing illicit recreational drugs. Synthetic cannabinoids (SCs) are a subclass of NPS …

[HTML][HTML] New synthetic cannabinoids metabolism and strategies to best identify optimal marker metabolites

X Diao, MA Huestis - Frontiers in chemistry, 2019 - frontiersin.org
Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the
endocannabinoid system and as novel pharmacotherapies, but are now highly abused. This …

Concise synthesis of potential 4-hydroxy-5-fluoropentyl side-chain metabolites of four synthetic cannabinoids

J Wallgren, A Rexander, E Vestling, H Liu, J Dahlén… - Synlett, 2020 - thieme-connect.com
Synthetic cannabinoids are a group of compounds that act on the CB1 receptor and are
used illicitly as substitutes for cannabis. Given the rapid and extensive metabolism of …

Analytical techniques for the detection of novel psychoactive substances and their metabolites

FT Peters, MR Meyer - Novel Psychoactive Substances, 2013 - Elsevier
The emergence of ever-novel psychoactive substances on the recreational drug market is
an ongoing challenge for analytical toxicologists. If still unknown, their structure must first be …

Identification of AKB-48 and 5F-AKB-48 metabolites in authentic human urine samples using human liver microsomes and time of flight mass spectrometry

S Vikingsson, M Josefsson… - Journal of analytical …, 2015 - academic.oup.com
The occurrence of structurally related synthetic cannabinoids makes the identification of
unique markers of drug intake particularly challenging. The aim of this study was to identify …

Profiling of in vitro metabolism of New Psychoactive Substances

A DI TRANA - 2022 - iris.univpm.it
Abstract A New Psychoactive Substance (NPS) is defined by United Nation Office of Drugs
and Drug Addiction (UNODC) as a “substance of abuse, either in a pure form or a …

[HTML][HTML] Untargeted metabolomics in forensic toxicology: A new approach for the detection of fentanyl intake in urine samples

E Amante, E Alladio, R Rizzo, D Di Corcia, P Negri… - Molecules, 2021 - mdpi.com
The misuse of fentanyl, and novel synthetic opioids (NSO) in general, has become a public
health emergency, especially in the United States. The detection of NSO is often challenged …

[HTML][HTML] Recent trends in drugs of abuse metabolism studies for mass spectrometry–based analytical screening procedures

L Wagmann, TM Gampfer, MR Meyer - Analytical and Bioanalytical …, 2021 - Springer
The still increasing number of drugs of abuse, particularly the so-called new psychoactive
substances (NPS), poses an analytical challenge for clinical and forensic toxicologists but …

Structure elucidation of novel synthetic opioid metabolites: New biomarkers of exposure in clinical and forensic toxicology

P Brunetti - 2023 - iris.univpm.it
The phenomenon of new psychoactive substances is constantly evolving, with novel
synthetic opioids (NSOs) representing a fast growing subclass. From 2014 onwards, illicit …