Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

Ever since the discovery of sirtuins a decade ago, interest in this family of NAD-dependent
deacetylases has exploded, generating multiple lines of evidence implicating sirtuins as …

Sirtuins are NAD+ dependent deacetylases that counter aging and diseases of aging. Sirtuin
research has focused on SirT1, which deacetylates transcription factors and cofactors in the …

Members of the sirtuin family of protein deacetylases support and promote longevity in
diverse organisms and can extend life span when upregulated. Sirtuin pathways also …

Brain aging is characterized by progressive loss of neurophysiological functions that is often
accompanied by age-associated neurodegeneration. Calorie restriction has been linked to …

Members of the sirtuin family of NAD+-dependent protein deacetylases are important
regulators of longevity in yeast, worms, and flies. Mammals have seven sirtuins (SIRT1-7) …

The sirtuins are highly conserved NAD‐dependent deacetylases that were shown to
regulate lifespan in lower organisms and affect diseases of aging in mammals, such as …

The sirtuin family of histone deacetylases (HDACs) was named after their homology to the
Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has …

The controversy around sirtuins and their functions in aging has drawn in the past few years
as much attention, if not more, from the scientific community and the public as they did when …