Pelvic Inflammatory Disease Due to Neisseria gonorrhoeae and Chlamydia trachomatis: Immune Evasion Mechanisms and Pathogenic Disease Pathways

T Darville - The Journal of infectious diseases, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) results from ascension of sexually transmitted pathogens
from the lower genital tract to the uterus and/or fallopian tubes in women, with potential …

[HTML][HTML] Pathogenesis of Neisseria gonorrhoeae and the host defense in ascending infections of human fallopian tube

JD Lenz, JP Dillard - Frontiers in immunology, 2018 - frontiersin.org
Neisseria gonorrhoeae is an obligate human pathogen that causes mucosal surface
infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva …

A review of the challenges and complexities in the diagnosis, etiology, epidemiology, and pathogenesis of pelvic inflammatory disease

SL Hillier, KT Bernstein, S Aral - The Journal of Infectious …, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) is a syndrome that causes substantial morbidity, including
chronic pelvic pain, to women globally. While limited data are available from low-and middle …

Etiology and diagnosis of pelvic inflammatory disease: looking beyond gonorrhea and chlamydia

CM Mitchell, GE Anyalechi, CR Cohen… - The Journal of …, 2021 - academic.oup.com
Pelvic inflammatory disease (PID) is a clinical syndrome that has been associated with a
wide range of potential causal pathogens. Three broad groups of organisms have been …

Chlamydial infection increases gonococcal colonization in a novel murine coinfection model

RA Vonck, T Darville, CM O'Connell… - Infection and …, 2011 - Am Soc Microbiol
Genital tract infections caused by Neisseria gonorrhoeae and Chlamydia trachomatis
serovars D to K occur at high incidence in many areas of the world. Despite high rates of …

Distinct Proinflammatory Host Responses to Neisseria gonorrhoeae Infection in Immortalized Human Cervical and Vaginal Epithelial Cells

RN Fichorova, PJ Desai, FC Gibson III… - Infection and …, 2001 - Am Soc Microbiol
In this study we utilized immortalized morphologically and functionally distinct epithelial cell
lines from normal human endocervix, ectocervix, and vagina to characterize gonococcal …

Neisseria gonorrhoeae Suppresses Dendritic Cell-Induced, Antigen-Dependent CD4 T Cell Proliferation

W Zhu, MS Ventevogel, KJ Knilans, JE Anderson… - PloS one, 2012 - journals.plos.org
Neisseria gonorrhoeae is the second most common sexually transmitted bacterial pathogen
worldwide. Diseases associated with N. gonorrhoeae cause localized inflammation of the …

Mouse Strain-Dependent Differences in Susceptibility to Neisseria gonorrhoeae Infection and Induction of Innate Immune Responses

M Packiam, SJ Veit, DJ Anderson, RR Ingalls… - Infection and …, 2010 - Am Soc Microbiol
Acute gonorrhea in women is characterized by a mucopurulent exudate that contains
polymorphonuclear leukocytes (PMNs) with intracellular gonococci. Asymptomatic infections …

Pathogenesis of Genital Tract Disease Due to Chlamydia trachomatis

T Darville, TJ Hiltke - The Journal of infectious diseases, 2010 - academic.oup.com
Although the pathologic consequences of C. trachomatis genital infection are well-
established, themechanism (s) that result in chlamydia-induced tissue damage are not fully …

Risk of pelvic inflammatory disease in relation to chlamydia and gonorrhea testing, repeat testing, and positivity: a population-based cohort study

J Reekie, B Donovan, R Guy, JS Hocking… - Clinical Infectious …, 2018 - academic.oup.com
Background There is uncertainty around whether the risks of pelvic inflammatory disease
(PID) differ following Chlamydia trachomatis (chlamydia) and Neisseria gonorrhoeae …