Osteosarcoma mechanobiology and therapeutic targets
Z Shoaib, TM Fan… - British journal of …, 2022 - Wiley Online Library
Osteosarcoma is one of the most common primary tumours of the bone, with a 5‐year
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …
survival rate of less than 20% after the development of metastases. Osteosarcoma is highly …
Mechanobiology of tumor growth
Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …
Biophysics in tumor growth and progression: from single mechano-sensitive molecules to mechanomedicine
Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …
between the biophysical tumor microenvironment and genetic regulation has significant …
Functions and clinical significance of mechanical tumor microenvironment: cancer cell sensing, mechanobiology and metastasis
H Zhou, M Wang, Y Zhang, Q Su, Z Xie… - Cancer …, 2022 - Wiley Online Library
Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …
Tissue engineering the cancer microenvironment—challenges and opportunities
V Papalazarou, M Salmeron-Sanchez… - Biophysical reviews, 2018 - Springer
Mechanosensing is increasingly recognised as important for tumour progression. Tumours
become stiff and the forces that normally balance in the healthy organism break down and …
become stiff and the forces that normally balance in the healthy organism break down and …
Mechano-therapeutics: targeting mechanical signaling in fibrosis and tumor stroma
DJ Tschumperlin, D Lagares - Pharmacology & therapeutics, 2020 - Elsevier
Pathological remodeling of the extracellular matrix (ECM) by activated myofibroblasts is a
hallmark of fibrotic diseases and desmoplastic tumors. Activation of myofibroblasts occurs in …
hallmark of fibrotic diseases and desmoplastic tumors. Activation of myofibroblasts occurs in …
[HTML][HTML] Role of the mechanical microenvironment in cancer development and progression
Q Liu, Q Luo, Y Ju, G Song - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …
Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases
Cross-talk between tumor cells and their microenvironment is critical for malignant
progression. Cross-talk mediators, including soluble factors and direct cell contact, have …
progression. Cross-talk mediators, including soluble factors and direct cell contact, have …
[HTML][HTML] Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis
X Li, J Wang - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …
related death. Metastatic disease or the movement of cancer cells from one site to another …
The osteosarcoma microenvironment: a complex but targetable ecosystem
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
adolescents, and young adults, and with a second peak of incidence in elderly individuals …