Graft rejection remains the major obstacle after vascularized solid organ transplantation.
Endothelial cells, which form the interface between the transplanted graft and the host's …

Allograft arteriopathy is a vascular intimal proliferative process that occurs in all solid organ
transplants and stands as the single most significant obstacle to successful long-term solid …

Solid organ transplantation is the only treatment for end-stage organ failure but this life-
saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels …

Vascularized composite allotransplantation (VCA) is an evolving field of reconstructive
surgery that has revolutionized the treatment of patients with devastating injuries, including …

Rationale: Transplant arteriosclerosis is the major limitation to long-term survival of solid
organ transplantation. Although both immune and nonimmune cells have been suggested to …

In organ transplantation, development of immunosuppressive treatment and improved
diagnosis of allograft rejection has resulted in increased allograft survival in recent years …

The lesion-promoting events and processes involved in the pathogenesis of transplant
vascular disease (TVD) are intimately dependent on the interactions of both endothelial cells …

Antibody-mediated rejection (AMR) of solid organ transplants is characterized by the
activation and injury of the allograft endothelium. Histological and transcriptomic studies …

Human vascularized allografts are perfused through blood vessels composed of cells
(endothelium, pericytes, and smooth muscle cells) that remain largely of graft origin and are …

Recent studies of endothelial cell biology have provided numerous original findings relevant
to transplantation. The molecular mechanisms utilized by endothelial cells to regulate cell …