Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study

RC Gardner, AM Puccio, FK Korley… - Brain …, 2023 - academic.oup.com
Older adults have the highest incidence of traumatic brain injury globally. Accurate blood-
based biomarkers are needed to assist with diagnosis of patients across the spectrum of age …

diagnostic utility of glial fibrillary acidic protein beyond 12 hours after traumatic brain injury: A TRACK-TBI study

AM Puccio, JK Yue, FK Korley, DO Okonkwo… - Journal of …, 2024 - liebertpub.com
Blood levels of glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl-terminal hydrolase-
L1 (UCH-L1) within 12h of suspected traumatic brain injury (TBI) have been approved by the …

Comparing glial fibrillary acidic protein (GFAP) in serum and plasma following mild traumatic brain injury in older adults

NA Huebschmann, TM Luoto, JE Karr… - Frontiers in …, 2020 - frontiersin.org
Objective: Identification and validation of blood-based biomarkers for the diagnosis and
prognosis of mild traumatic brain injury (mTBI) is of critical importance. There have been …

Accuracy of a rapid glial fibrillary acidic protein/ubiquitin carboxyl‐terminal hydrolase L1 test for the prediction of intracranial injuries on head computed tomography …

JJ Bazarian, RD Welch, K Caudle… - Academic …, 2021 - Wiley Online Library
Objective The objective was to determine the accuracy of a new, rapid blood test combining
measurements of both glial fibrillary acidic protein (GFAP) and ubiquitin carboxyl‐terminal …

Incremental prognostic value of acute serum biomarkers for functional outcome after traumatic brain injury (CENTER-TBI): an observational cohort study

IRAR Helmrich, E Czeiter, K Amrein, A Büki… - The Lancet …, 2022 - thelancet.com
Background Several studies have reported an association between serum biomarker values
and functional outcome following traumatic brain injury. We aimed to examine the …

[HTML][HTML] Blood biomarkers for traumatic brain injury: A narrative review of current evidence

I Hossain, N Marklund, E Czeiter, P Hutchinson, A Buki - Brain and spine, 2023 - Elsevier
Introduction A blood-based biomarker (BBBM) test could help to better stratify patients with
traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary …

Examining four blood biomarkers for the detection of acute intracranial abnormalities following mild traumatic brain injury in older adults

GL Iverson, M Minkkinen, JE Karr, K Berghem… - Frontiers in …, 2022 - frontiersin.org
Blood-based biomarkers have been increasingly studied for diagnostic and prognostic
purposes in patients with mild traumatic brain injury (MTBI). Biomarker levels in blood have …

Utility of serum biomarkers in the diagnosis and stratification of mild traumatic brain injury

LM Lewis, DT Schloemann, L Papa… - Academic …, 2017 - Wiley Online Library
Objective The objective was to compare test characteristics of a single serum concentration
of glial fibrillary acidic protein (GFAP), S‐100β, and ubiquitin carboxyl terminal hydrolase L1 …

Point-of-care platform blood biomarker testing of glial fibrillary acidic protein versus S100 calcium-binding protein B for prediction of traumatic brain injuries: a …

DO Okonkwo, RC Puffer, AM Puccio, EL Yuh… - Journal of …, 2020 - liebertpub.com
Glial fibrillary acidic protein (GFAP) is cleared by the Food and Drug Administration (FDA) to
determine need for head computed tomography (CT) within 12 h after mild traumatic brain …

Blood biomarkers in brain injury medicine

WR McBride, CE Conlan, NA Barylski… - … physical medicine and …, 2022 - Springer
Abstract Purpose of Review This review seeks to explore blood-based biomarkers with the
potential for clinical implementation. Recent Findings Emerging non-proteomic biomarkers …