Genomic reprogramming of primordial germ cells (PGCs), which includes genome‐wide
demethylation, prevents aberrant epigenetic modifications from being transmitted to …

Expression of imprinted genes is dependent on their parental origin. This is reflected in the
heritable differential methylation of parental alleles. The gametic imprints are however …

Germ cells undergo epigenetic modifications as they develop, which suggests that they may
be ideal donors for nuclear transfer (cloning). In this study, nuclei from confirmed embryonic …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

There are distinctive and characteristic genomic modifications in primordial germ cells that
distinguish the germ cell lineage from somatic cells. These modifications include, genome …

Imprinting is an epigenetic modification leading to monoallelic expression of some genes,
and disrupted imprinting is believed to be a barrier to human stem cell transplantation …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

Pluripotent stem cells termed embryonic germ cells (EGCs) have earlier been derived from
pre-and post-migrating mouse primordial germ cells (PGCs). We have recently obtained four …

Genomic imprinting is an epigenetic mechanism that causes functional differences between
paternal and maternal genomes, and plays an essential role in mammalian development …

DNA methylation is an essential epigenetic mechanism involved in many essential cellular
processes. During development epigenetic reprograming takes place during gametogenesis …