Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Recent mechanistic insights on glycoconjugate vaccines and future perspectives

F Berti, R Adamo - ACS Chemical Biology, 2013 - ACS Publications
Vaccination is a key strategy for the control of various infectious diseases. Many pathogens,
such as Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), and Neisseria …

Recent advances in the synthesis of glycoconjugates for vaccine development

C Colombo, O Pitirollo, L Lay - Molecules, 2018 - mdpi.com
During the last decade there has been a growing interest in glycoimmunology, a relatively
new research field dealing with the specific interactions of carbohydrates with the immune …

[PDF][PDF] A coordinated synthesis and conjugation strategy for the preparation of homogeneous glycoconjugate vaccine candidates

EJ Grayson, GJL Bernardes, JM Chalker… - Angewandte Chemie …, 2011 - users.ox.ac.uk
Glycoconjugates are the center of many therapeutic strategies [1–3] and carbohydrate-
based vaccines in particular hold great promise.[4–8] The development of glycovaccines …

Emerging themes in medicinal glycoscience

KM Koeller, CH Wong - Nature biotechnology, 2000 - nature.com
The recognition of complex carbohydrates and glycoconjugates as mediators of important
biological processes has stimulated investigation into their therapeutic potential. New …

Recent developments in glycoconjugates

BG Davis - Journal of the Chemical Society, Perkin Transactions 1, 1999 - pubs.rsc.org
6.2 Phosphorylation 6.3 Pyruvate acetals 6.4 Acetylation 7 Glycoconjugate libraries 8
Applications and uses 8.1 Probing protein activity, function and mechanism 8.2 Drug …

Exploring and exploiting the therapeutic potential of glycoconjugates

KJ Doores, DP Gamblin… - Chemistry–A European …, 2006 - Wiley Online Library
Carbohydrates, either bound to proteins or in lipids, play essential roles as communication
molecules in many intercellular and intracellular processes. In particular, carbohydrates are …

Combined approaches to the synthesis and study of glycoproteins

GJL Bernardes, B Castagner… - ACS Chemical …, 2009 - ACS Publications
Carbohydrates are the basis for many therapeutic and diagnostic strategies, yet the full
potential of glycans in medicine has not been realized. The study of the precise role of …

Carbohydrate based vaccines

B Kuberan, RJ Linhardt - Current Organic Chemistry, 2000 - ingentaconnect.com
Vaccination is the most cost-efficient and the most powerful medical intervention in the
control, prevention and eradication of many diseases that affect human population. Capsular …

Glycals in organic synthesis: the evolution of comprehensive strategies for the assembly of oligosaccharides and glycoconjugates of biological consequence

SJ Danishefsky, MT Bilodeau - … Chemie International Edition in …, 1996 - Wiley Online Library
This review provides a personal account of the explorations of a research group in
oligosaccharide and glycoconjugate construction. The journey began twenty years ago with …