Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

The extracellular matrix (ECM) plays important roles in maintaining physiological structure
and functions of various tissues and organs. Cardiac fibrosis is the excess deposition of …

Fibrosis, characterized by an excessive accumulation of extracellular matrix, has long been
seen as an adaptive process that contributes to tissue healing and regeneration. More …

Inflammatory and fibrotic responses to myocardial damage are essential for cardiac repair;
however, these responses often result in extensive fibrotic remodeling with impaired systolic …

Myocardial fibrosis is the result of excessive fibrillar collagen synthesis and deposition
without reciprocally balanced degradation. It causes cardiac dysfunction, arrhythmias, and …

Cardiac fibrosis remains an unresolved problem in heart diseases. After initial injury, cardiac
fibroblasts (CFs) are activated and subsequently differentiate into myofibroblasts (myoFbs) …

Cardiac fibrosis is a significant global health problem that is closely associated with multiple
forms of cardiovascular disease, including myocardial infarction, dilated cardiomyopathy …

Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease.
Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia …

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the
cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many …