Sigma 1 receptor (S1R) is a 223-amino-acid-long transmembrane endoplasmic reticulum
(ER) protein. S1R modulates activity of multiple effector proteins and is a well-established …

The sigma-1 receptor (S1R) is a 223 amino acid-long transmembrane endoplasmic
reticulum (ER) protein. The S1R modulates the activity of multiple effector proteins, but its …

The Sigma-1 receptor (S1R) is a transmembrane protein with important roles in cellular
homeostasis in normal physiology and in disease. Especially in neurodegenerative …

The brain σ-1 receptors can bind neurosteroids and psychotropic drugs, including
neuroleptics and cocaine and are implicated in schizophrenia, depression, and drug …

Abstract The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane
protein involved in cell homeostasis and the cellular stress response. The receptor has a …

Despite substantial data elucidating the roles of cholesterol in lipid rafts at the plasma
membrane, the roles of cholesterol and related lipids in lipid raft microdomains at the level of …

Deciphering the role of any protein in a cell requires knowledge of the structure, subcellular
localization, and the topological orientation of the protein within the relevant cells. The …

Abstract The sigma-1 receptor (S1R) is a ligand-regulated membrane chaperone protein
associated with endoplasmic reticulum stress response, and modulation of ion channel …

σ-1 receptors (Sig-1Rs) that bind diverse synthetic and endogenous compounds have been
implicated in the pathophysiology of several human diseases such as drug addiction …

SR31747A is a sigma ligand previously described as having original immunosuppressive
properties. Two SR31747A targets were recently identified and termed sigma1 or SR‐BP‐1 …