Background Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and
mortality. Little is known about the factors that contribute to the chronic inflammatory state …

The mitochondrial free radical theory of aging suggests that accumulating oxidative damage
to mitochondria and mitochondrial DNA (mtDNA) plays a central role in aging. Circulating …

Figure 1. Mitochondrial DNA in extracellular vesicles and association with human aging.(A)
Damage to mitochondria can lead to release of mitochondrial components, including …

Background Dementia and frailty are common age-related syndromes often linked to chronic
inflammation. Identifying the biological factors and pathways that contribute to chronic …

Background: Interplays between inflammation and mitochondrial biology are reported. Here,
we examined the cross-sectional interrelationships of mitochondrial DNA copy number …

Mitochondrial components, including mitochondrial DNA (mtDNA), when released
extracellularly, can act as “damage‐associated molecular pattern”(DAMP) agents and cause …

Mitochondrial dysfunction and systemic inflammation are major factors in the development of
sarcopenia, but the molecular determinants linking the two mechanisms are only partially …

Even before the COVID-19 pandemic declines in life expectancy in the United States were
attributed to increased mortality rates in midlife adults across racial and ethnic groups …

Objective To evaluate the circulating cell-free mitochondrial DNA (ccf-mtDNA) levels, a
marker of cellular stress and damage, in older adults with late-life depression (LLD) and …

Aging is associated with changes in the immune system, increased inflammation and
mitochondrial dysfunction. The relationship between these phenomena and the clinical …