[HTML][HTML] γδ T Cells: A Game Changer in the Future of Hepatocellular Carcinoma Immunotherapy

SP Papadakos, K Arvanitakis, IE Stergiou… - International journal of …, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) remains a global health challenge with limited treatment
options and a poor prognosis for advanced-stage patients. Recent advancements in cancer …

Gamma delta T cells: role in immunotherapy of hepatocellular carcinoma

KC Amajala, IP Gudivada… - Critical Reviews™ in …, 2023 - dl.begellhouse.com
The most typical type of liver cancer or hepatocellular carcinoma (HCC) develops from
hepatocyte loss. Non-alcoholic fatty liver disease (NAFLD), viral hepatitis C and cirrhosis are …

[HTML][HTML] Immune Regulatory Networks and Therapy of γδ T Cells in Liver Cancer: Recent Trends and Advancements

KL Yin, KJ Chu, M Li, YX Duan, YX Yu… - Journal of Clinical …, 2024 - ncbi.nlm.nih.gov
The roles of γδ T cells in liver cancer, especially in the potential function of immunotherapy
due to their direct cytotoxic effects on tumor cells and secretion of important cytokines and …

[HTML][HTML] γδ T cell-mediated individualized immunotherapy for hepatocellular carcinoma considering clinicopathological characteristics and immunosuppressive factors

W Tian, J Ma, R Shi, C Ren, J He… - Oncology …, 2018 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer. γδ T cells
have been revealed to be promising candidates for immunotherapy in patients with HCC …

γδ T cells: The potential role in liver disease and implications for cancer immunotherapy

H Ren, WJ Li, X Liu, N Zhao - Journal of Leukocyte Biology, 2022 - academic.oup.com
The γδ T cell subset was discovered over 30 years ago, yet continues to be an exciting and
challenging component of the adaptive immune response. While γδ T cells represent a very …

Hepatocellular carcinoma‐infiltrating γδ T cells are functionally defected and allogenic Vδ2+ γδ T cell can be a promising complement

W He, Y Hu, D Chen, Y Li, D Ye, Q Zhao… - Clinical and …, 2022 - Wiley Online Library
In hepatocellular carcinoma (HCC), γδ T cells participate in mediating the anti‐tumour
response and are linked with a positive prognosis. However, these cells can become pro …

The functional impairment of HCC-infiltrating γδ T cells, partially mediated by regulatory T cells in a TGFβ-and IL-10-dependent manner

Y Yi, HW He, JX Wang, XY Cai, YW Li, J Zhou… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: The immunosuppressive network within the tumor
microenvironment is one of the major obstacles to the success of cancer immunotherapy. γδ …

γδ T cells in hepatocellular carcinoma patients present cytotoxic activity but are reduced in potency due to IL-2 and IL-21 pathways

H Jiang, Z Yang, Z Song, M Green, H Song… - International …, 2019 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver carcinoma and has one
of the highest mortality rates of all cancers. The γδ T cells could infiltrate HCC and have …

Identification of new potential antigen recognized by γδT cells in hepatocellular carcinoma

X Xi, Y Guo, M Zhu, F Qiu, F Lei, G Li, B Du - Cancer Immunology …, 2021 - Springer
In recent years, the application of chimeric antigen receptor T-cell (CAR-T) therapy based on
gamma delta T (γδT) cells in hepatocellular carcinoma (HCC) immunotherapy has attracted …

Gamma delta (γδ) T cells in cancer immunotherapy; where it comes from, where it will go?

J Deng, H Yin - European Journal of Pharmacology, 2022 - Elsevier
Cancer immunotherapy is a field of interest in the recent treatment approaches against
cancer cells, as it could use the assets of the host's immune system against the invading …