Punicalagin inhibited inflammation and migration of fibroblast-like synoviocytes through NF-κB pathway in the experimental study of rheumatoid arthritis

M Huang, K Wu, S Zeng, W Liu, T Cui… - Journal of …, 2021 - Taylor & Francis
Background The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in
the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural …

Panaxynol induces fibroblast-like synovial cell apoptosis, inhibits proliferation and invasion through TLR4/NF-κB pathway to alleviate rheumatoid arthritis

Y Zhao, X Sun, J Lin, T Zhang, S Liu, Z Yan - International …, 2021 - Elsevier
Background and purpose Panaxynol (PAL, PubChem CID: 5281149) is a common natural
minor component in Umbelliferae plants, such as Radix Saposhnikoviae Divaricatae …

Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition

QN Baito, HM Jaafar, TAM Mohammad - Cellular Immunology, 2023 - Elsevier
Rheumatoid Arthritis (RA) is a common autoimmune disease recognized by hyperplasia of
synoviocytes and chronic joint inflammation. Activation of fibroblast-like synoviocytes (FLSs) …

Protective effects of paeonol on inflammatory response in IL-1β-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-κB …

K Zhai, H Duan, L Luo, W Cao, F Han, L Shan… - …, 2017 - Springer
Various investigations have demonstrated that human fibroblast-like synoviocytes
rheumatoid arthritis (HFLS-RA) take part in the chronic inflammatory responses and RA …

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway

G Ge, J Bai, Q Wang, X Liang, H Tao, H Chen… - Science China Life …, 2022 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease that eventually leads to
disability. Inflammatory cell infiltration, severe joint breaking and systemic bone loss are the …

Protocatechuic acid inhibits proliferation, migration and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes

H Wu, J Wang, Q Zhao, Y Ding, B Zhang… - Artificial Cells …, 2020 - Taylor & Francis
Rheumatoid arthritis (RA) is a chronic joint inflammatory disease that is closely associated
with dysregulation of fibroblast-like synoviocytes (FLSs). Protocatechuic acid (PCA), a …

Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes by inhibiting the NF‑κB and MAPK signaling …

X Gao, X Kang, H Lu, E Xue… - Molecular …, 2022 - spandidos-publications.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease that mainly targets the synovial
membrane, thus causing stiffness, deformity and dysfunction of joints. To date, no effective …

Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis

N Li, Z Gong, X Li, Q Ma, M Wu, D Liu, L Deng… - International …, 2019 - Elsevier
The aggressive phenotype displayed by fibroblast-like synoviocytes (FLSs) contributes to
cartilage and bone destruction in rheumatoid arthritis (RA). Betulinic acid has been …

Sodium tanshinone IIA sulfonate inhibits proliferation, migration, invasion and inflammation in rheumatoid arthritis fibroblast-like synoviocytes

Z Wang, J Li, J Zhang, X Xie - International Immunopharmacology, 2019 - Elsevier
Our study aimed to determine the effects of sodium tanshinone IIA sulfonate (STS) on
proliferation, migration, invasion, and inflammation in rheumatoid arthritis human fibroblast …

Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway

D Pan, N Li, Y Liu, Q Xu, Q Liu, Y You, Z Wei… - International …, 2018 - Elsevier
In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLSs) play an essential role in
cartilage destruction. Aggressive migration and invasion by FLSs significantly affect RA …