Many drugs of abuse, including cannabinoids, opioids, alcohol and nicotine, can alter the
levels of endocannabinoids in the brain. Recent studies show that release of …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …

Cannabis is the most commonly abused illegal drug in the world and its main psychoactive
ingredient, delta-9-tetrahydrocannabinol (THC), produces rewarding effects in humans and …

Pharmacologic treatment of drug and alcohol dependency has largely been disappointing,
and new therapeutic targets and hypotheses are needed. There is accumulating evidence …

Since the identification and cloning of the major cannabinoid receptor expressed in the brain
almost 25 years ago research has highlighted the potential of drugs that target the …

This review aims to present the more recent knowledge on the role of the endocannabinoid
system in drug addiction. For a long time, dopamine has been consistently associated with …

The last decades have seen a major gain in understanding the action of cannabinoids and
the endocannabinoid system in reward processing and the development of addictive …

This review will discuss the latest knowledge of how the endocannabinoid system might be
involved in treating addiction to the most common illicit drugs. Experimental models are …

Drug dependence is a chronically relapsing disorder, manifested as an intense desire for
the drug, with impaired ability to control the urges to take the drug, even at the expense of …

Substantial evidence suggests that all commonly abused drugs act upon the brain reward
circuitry to ultimately increase extracellular concentrations of the neurotransmitter dopamine …