In the complex network of nuclear hormone receptors, the long non-coding RNAs (lncRNAs)
are emerging as critical determinants of hormone action. Here we investigated the …

Understanding the mechanisms of androgen receptor (AR) activation in the milieu of low
androgen is critical to effective treatment of castration-resistant prostate cancer (CRPC) …

Long non-coding RNAs (lncRNAs) are emerging as novel diagnostic markers of prostate
cancer (PCa) and new determinants of castration-resistant PCa (CRPC), an aggressive and …

As one of the most frequently diagnosed cancers in males, the development and
progression of prostate cancer remains an open area of research. The role of lncRNAs in …

Long non-coding RNAs (lncRNAs) exert central pathophysiological roles through the
regulation of gene expression both at transcriptional and post-transcriptional levels. The …

Abstract HOTAIR (HOX antisense intergenic RNA) is a 2.2 kb long non-coding RNA
(lncRNA), transcribed from the antisense strand of homeobox C (HOXC) gene locus in …

Recent large-scale transcriptome analyses have revealed that transcription is spread
throughout the mammalian genomes, yielding large numbers of transcripts, including l ong n …

With the advent of next generation sequencing methods and progress in transcriptome
analysis, it became obvious that the human genome contains much more than just protein …

The importance of long non-coding RNAs (lncRNAs) in the pathogenesis of various
malignancies has been uncovered over the last few years. Their dysregulation often …

Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer
and the development of resistance represents a major obstacle for a cure. Although long …