A significant contributor to the obesity epidemic is the overconsumption of highly palatable,
energy dense foods. Chronic intake of palatable foods is associated with neuroadaptations …

Obesity is a costly, global epidemic that is perpetuated by an unhealthy diet. A significant
factor in the initial consumption and maintenance of an unhealthy diet is the abundance of …

Environmental variations can influence eating and motivated behaviors, as well as the
brain's feeding circuits to predisposing overweight and obesity. The identification of …

Highlights•Chronic high-fat feeding modulates dopamine tone and function.•The impact of
high-fat diet on dopamine-related endpoints is inconsistent.•Classification of results …

Overweight and obesity in the United States continues to grow at epidemic rates in large part
due to the overconsumption of calorically-dense palatable foods. Identification of factors …

Consumption of a high-fat diet has been linked to obesity, dyslipidemia and cardiovascular
disease. Less well appreciated are adverse effects on the brain and behavior. Recent …

Objective: To identify the emotional and motivational processes that reinstate palatable food
intake following removal of high-fat diet (HFD) and associated neuroadaptations tied to …

Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

Objective We have previously demonstrated that insulin signaling, through the downstream
signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine …

Increasing evidence suggest that consumption of high-fat diet (HFD) can impact the
maturation of brain circuits, such as during adolescence, which could account for behavioral …