[HTML][HTML] Hoxa11-mediated reduction of cell migration contributes to myeloid sarcoma formation induced by cooperation of MLL/AF10 with activating KRAS mutation in …
JF Fu, CJ Wen, TH Yen, LY Shih - Neoplasia, 2022 - Elsevier
The molecular mechanism of myeloid sarcoma (MS) formation remains nuclear. Our clinical
and mouse model findings from a previous study revealed that cooperation of KMT2A (MLL) …
and mouse model findings from a previous study revealed that cooperation of KMT2A (MLL) …
HOXA9 is required for survival in human MLL-rearranged acute leukemias
J Faber, AV Krivtsov, MC Stubbs… - Blood, The Journal …, 2009 - ashpublications.org
Leukemias that harbor translocations involving the mixed lineage leukemia gene (MLL)
possess unique biologic characteristics and often have an unfavorable prognosis. Gene …
possess unique biologic characteristics and often have an unfavorable prognosis. Gene …
HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways
R Miyamoto, A Kanai, H Okuda, Y Komata… - Elife, 2021 - elifesciences.org
HOXA9 is often highly expressed in leukemias. However, its precise roles in
leukemogenesis remain elusive. Here, we show that HOXA9 maintains gene expression for …
leukemogenesis remain elusive. Here, we show that HOXA9 maintains gene expression for …
Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM‐LZ) and oncogenic KRAS in a mouse bone marrow transplantation …
JF Fu, TH Yen, Y Chen, YJ Huang… - … journal of cancer, 2013 - Wiley Online Library
Oncogenic N‐/KRAS mutations were frequently associated with MLL/AF10 in acute myeloid
leukemia with myeloid sarcoma (MS). To study the cooperating leukemogenesis by …
leukemia with myeloid sarcoma (MS). To study the cooperating leukemogenesis by …
Two isoforms of HOXA9 function differently but work synergistically in human MLL-rearranged leukemia
M He, P Chen, S Arnovitz, Y Li, H Huang… - Blood Cells, Molecules …, 2012 - Elsevier
HOXA9 plays a critical role in both normal hematopoiesis and leukemogenesis, particularly
in the development and maintenance of mixed lineage leukemia (MLL)-rearranged …
in the development and maintenance of mixed lineage leukemia (MLL)-rearranged …
[HTML][HTML] HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia
G Brumatti, M Salmanidis, CH Kok, RA Bilardi… - Oncotarget, 2013 - ncbi.nlm.nih.gov
Deregulated expression of Hox genes such as HoxA9 is associated with development of
myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate …
myeloproliferative disorders and leukemia and indicates a poor prognosis. To investigate …
Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells
V Martino, A Bianchera, L Reia… - Molecular …, 2009 - spandidos-publications.com
The translocation t (9; 11)(p22; q23) generates the MLL-AF9 oncogene and is commonly
associated with monocytic acute myeloid leukemia (AML-M5; FAB-classification). For the …
associated with monocytic acute myeloid leukemia (AML-M5; FAB-classification). For the …
Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation
U Vijapurkar, N Fischbach, W Shen… - … and cellular biology, 2004 - Taylor & Francis
HOXA9 expression is a common feature of acute myeloid leukemia, and high-level
expression is correlated with poor prognosis. Moreover, HOXA9 overexpression …
expression is correlated with poor prognosis. Moreover, HOXA9 overexpression …
HOXA9 is critical in the proliferation, differentiation, and malignancy of leukaemia cells both in vitro and in vivo
S Chen, J Yu, X Lv, L Zhang - Cell biochemistry and function, 2017 - Wiley Online Library
Progress in the understanding of the molecular mechanism for acute myeloid leukaemia is
of great significance to generate new potential targets for treatment. Recent studies showed …
of great significance to generate new potential targets for treatment. Recent studies showed …
Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation
R Ono, H Kumagai, H Nakajima, A Hishiya, T Taki… - Leukemia, 2009 - nature.com
Abstract Mixed-lineage-leukemia (MLL) fusion oncogenes are closely involved in infant
acute leukemia, which is frequently accompanied by mutations or overexpression of FMS …
acute leukemia, which is frequently accompanied by mutations or overexpression of FMS …