Mutations in the KRAS proto-oncogene are present in 50% of all colorectal cancers and are
increasingly associated with chemotherapeutic resistance to frontline biologic drugs …

Mitophagy is a selective form of macroautophagy in which dysfunctional and damaged
mitochondria can be efficiently degraded, removed and recycled through autophagy …

Many anticancer agents exert cytotoxicity and trigger apoptosis through the induction of
mitochondrial dysfunction. Mitophagy, as a key mitochondrial quality control mechanism …

The effectiveness of chemotherapy is largely limited by drug resistance. In the past few
decades, modulation of anticancer drug resistance plays little role in benefit of clinical …

Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …

Mitochondria as a signaling platform play crucial roles in deciding cell fate. Many classic
anticancer agents are known to trigger cell death through induction of mitochondrial …

Mitophagy is an evolutionarily conserved cellular process which selectively eliminates
dysfunctional mitochondria by targeting them to the autophagosome for degradation …

Background: In hypoxic tumors, positive feedback between oncogenic KRAS and HIF-1α
involves impressive metabolic changes correlating with drug resistance and poor prognosis …

Background Mitophagy refers to the selective self‐elimination of mitochondria under
damaged or certain developmental conditions. As an important regulatory mechanism to …

Cancer stem cells (CSCs) are distinct subpopulations of cancer cells with stem cell-like
abilities and are more resilient to chemotherapy, causing tumor relapse. Mitophagy, a …