Background Antibodies that protect against Plasmodium falciparum (Pf) malaria are only
acquired after years of repeated infections. The B cell biology that underlies this observation …

Epidemiological observations in malaria endemic areas have long suggested a deficiency in
the generation and maintenance of B cell memory to Plasmodium falciparum (Pf) in …

Immunity to Plasmodium falciparum (Pf) malaria is only acquired after years of repeated
infections and wanes rapidly without ongoing parasite exposure. Antibodies are central to …

Antibodies can protect from Plasmodium falciparum (Pf) infection and clinical malaria
disease. However, in the absence of constant reexposure, serum immunoglobulin (Ig) levels …

Humans respond to foreign antigen by generating plasma Abs and memory B cells (MBCs).
The Ab response then declines, sometimes to below the limit of detection. In contrast, MBCs …

Background Malaria caused by Plasmodium falciparum remains a major cause of death in
sub-Saharan Africa. Immunity against symptoms of malaria requires repeated exposure …

Exposure to Plasmodium falciparum is associated with circulating “atypical” memory B cells
(atMBCs), which appear similar to dysfunctional B cells found in HIV-infected individuals …

Naturally acquired iummunity against clinical malaria is slow to develop, taking years of
repeated exposure to parasites to acquire sufficiently broad and potent antibody responses …

For development of a long-lasting protective malaria vaccine, it is crucial to understand
whether Plasmodium-induced memory B cells (MBCs) or plasma cells develop and stably …

Background Several studies indicate that people of the Fulani ethnic group are less
susceptible to malaria compared to those of other ethnic groups living sympatrically in Africa …