Background & Aims: Obesity increases the risk of colon cancer, whereas physical activity
reduces the risk. Plasma levels of leptin increase in proportion to the level of obesity and are …

Background and aims Obesity increases the risk of colorectal cancer (CRC). Serum leptin
levels are markedly elevated in obese individuals, but the involvement of leptin in CRC …

Background and aims: Leptin, the product of the ob gene, has been suggested to increase
the risk of colon cancer. However, we have shown that although leptin stimulates epithelial …

Background: Leptin is an adipocyte-derived neurohormone, high levels of which are found
in obese individuals. Leptin controls energy expenditure, acting in the brain, and regulates …

Obesity is associated with an increased risk of colorectal cancer. Circulating levels of leptin
are high in obesity and strongly correlated to levels of insulin. Leptin stimulates growth of …

Background Obesity is associated with increased levels of leptin. The mitogenic actions of
leptin have been identified in various cell types. Because obesity may be a risk factor for …

Leptin plays a key role regulating food intake, body weight and fat mass. These critical
parameters are associated with an increased risk for digestive and mammary gland cancer …

Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer.
Methods: A case-control study nested in the Japan Collaborative Cohort Study. We …

Background and aims Obesity is a major risk factor for the development of colon cancer.
Secretion of the hormone leptin from adipocytes is increased in obesity, and serum levels …

Increased visceral adipose tissue results in elevated plasma leptin, which are associated
with increased risk of a number of obesity-related cancers. However, research is …