Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Histones form the protein core around which genomic DNA is wrapped in eukaryotic
chromatin. Numerous genetic studies have established that the structure and transcriptional …

Histone proteins and their accompanying post-translational modifications have received
much attention for their ability to affect chromatin structure and, hence, regulate gene …

Highlights•A useful reference for quantitative analysis of histone modifications.•Three
general approaches to analyze histone modifications by mass spectrometry.•Analytical …

Post-translational modifications of histones serve as docking sites and signals for effector
proteins and chromatin-remodeling enzymes, thereby influencing many fundamental cellular …

1. INTRODUCTION In eukaryotic cells, inheritable information is stored in a nucleoprotein
complex referred to as chromatin. 1 This genome architecture serves two key purposes. On …

Histone proteins are decorated by a variety of protein posttranslational modifications called
histone marks that modulate chromatin structure and function, contributing to the cellular …

DNA and histone modifications direct the functional state of chromatin and thereby the
readout of the genome. Candidate approaches and histone peptide affinity purification …

The N-terminal tails of the four core histones are subject to several types of covalent post-
translational modifications that have specific roles in regulating chromatin structure and …

The core histones are the primary protein component of chromatin, which is responsible for
the packaging of eukaryotic DNA. The NH2‐terminal tail domains of the core histones are …