Corneal endothelium is mostly sensitive to oxidative pressure and mitochondrial
dysfunction. However, the oxidative-antioxidant mechanism of corneal endothelial cells …

Intense exposure to light, robust metabolic activity, and high oxygen tension render the
human eye particularly vulnerable to oxidativedamage and the list of ophthalmological …

Purpose: Sirtuin1 (SIRT1) as a hot therapeutic target for oxidative stress–associated
diseases that has been extensively studied. This study aimed to determine the changes in …

Purpose: This study aims to test the hypothesis that sirtuin type 1 (SIRT1) plays a role in
modulating resistance against oxidative stress in lens epithelial cells (LECs), and to …

Aims The objectives of this study were to explore physiological and pathological changes in
the corneas of diabetic rats by intervening in the expression of silent information regulator 1 …

Due to continuous exposure to ultraviolet B (UVB) radiation, eye lenses are constantly
subjected to oxidative stress that induces lens epithelial cell (LEC) apoptosis, which has …

Purpose: To investigate the protective role of SRT1720 (SIRT1 activator) against the
oxidative stress caused by H2O2 in the corneal cell line. Methods: Human corneal (2.040 …

Purpose To investigate the protective role of SRT1720 (SIRT1 activator) against the
oxidative stress caused by H 2 O 2 in the corneal cell line. Methods Human corneal (2.040 …

Purpose: Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide
(NAD+) dependent deacetylase, which plays an essential role in cellular metabolism …

Purpose: Sirt1, the most well-known sirtuin family (class III histone deacetylases) member, is
involved in many age-related diseases. This study was to investigate its relationship with …