[HTML][HTML] The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms
LE de Vries, I Huitinga, HW Kessels, DF Swaab… - Molecular …, 2024 - Springer
Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …
Resistance and resilience to Alzheimer's disease
CS Latimer, KE Prater… - Cold Spring …, 2024 - perspectivesinmedicine.cshlp.org
Dementia is a significant public health crisis; the most common underlying cause of age-
related cognitive decline and dementia is Alzheimer's disease neuropathologic change …
related cognitive decline and dementia is Alzheimer's disease neuropathologic change …
[HTML][HTML] Understanding the molecular basis of resilience to Alzheimer's disease
KS Montine, E Berson, T Phongpreecha… - Frontiers in …, 2023 - frontiersin.org
The cellular and molecular distinction between brain aging and neurodegenerative disease
begins to blur in the oldest old. Approximately 15–25% of observations in humans do not fit …
begins to blur in the oldest old. Approximately 15–25% of observations in humans do not fit …
Cognitive resilience in brain health and dementia research
MS Joshi, JE Galvin - Journal of Alzheimer's Disease, 2022 - content.iospress.com
With the expected rise in Alzheimer's disease and related dementias (ADRD) in the coming
decades due to the aging population and a lack of effective disease-modifying treatments …
decades due to the aging population and a lack of effective disease-modifying treatments …
[HTML][HTML] From theory to practice: translating the concept of cognitive resilience to novel therapeutic targets that maintain cognition in aging adults
AR Zammit, DA Bennett, AS Buchman - Frontiers in Aging …, 2024 - frontiersin.org
While the concept of cognitive resilience is well-established it has not been defined in a way
that can be measured. This has been an impediment to studying its underlying biology and …
that can be measured. This has been an impediment to studying its underlying biology and …
Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer's disease
Although neuritic plaques and neurofibrillary tangles in older adults are correlated with
cognitive impairment and severity of dementia, it has long been recognized that the …
cognitive impairment and severity of dementia, it has long been recognized that the …
[HTML][HTML] Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial …
LE de Vries, A Jongejan, J Monteiro Fortes… - Acta neuropathologica …, 2024 - Springer
Some individuals show a discrepancy between cognition and the amount of
neuropathological changes characteristic for Alzheimer's disease (AD). This phenomenon …
neuropathological changes characteristic for Alzheimer's disease (AD). This phenomenon …
Resistance vs resilience to Alzheimer disease: clarifying terminology for preclinical studies
EM Arenaza-Urquijo, P Vemuri - Neurology, 2018 - AAN Enterprises
Preventing or delaying Alzheimer disease (AD) through lifestyle interventions will come from
a better understanding of the mechanistic underpinnings of (1) why a significant proportion …
a better understanding of the mechanistic underpinnings of (1) why a significant proportion …
Cognitive and functional resilience despite molecular evidence of Alzheimer's disease pathology
S Negash, S Xie, C Davatzikos, CM Clark… - Alzheimer's & …, 2013 - Elsevier
BACKGROUND: The correlation between neuropathological lesions and cognition is
modest. Some individuals remain cognitively intact despite the presence of significant …
modest. Some individuals remain cognitively intact despite the presence of significant …