Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …

Dementia is a significant public health crisis; the most common underlying cause of age-
related cognitive decline and dementia is Alzheimer's disease neuropathologic change …

The cellular and molecular distinction between brain aging and neurodegenerative disease
begins to blur in the oldest old. Approximately 15–25% of observations in humans do not fit …

With the expected rise in Alzheimer's disease and related dementias (ADRD) in the coming
decades due to the aging population and a lack of effective disease-modifying treatments …

While the concept of cognitive resilience is well-established it has not been defined in a way
that can be measured. This has been an impediment to studying its underlying biology and …

Although neuritic plaques and neurofibrillary tangles in older adults are correlated with
cognitive impairment and severity of dementia, it has long been recognized that the …

Some individuals show a discrepancy between cognition and the amount of
neuropathological changes characteristic for Alzheimer's disease (AD). This phenomenon …

Preventing or delaying Alzheimer disease (AD) through lifestyle interventions will come from
a better understanding of the mechanistic underpinnings of (1) why a significant proportion …

BACKGROUND: The correlation between neuropathological lesions and cognition is
modest. Some individuals remain cognitively intact despite the presence of significant …