Can the new adipokine asprosin be a metabolic troublemaker for cardiovascular diseases? A state-of-the-art review

Z Zhang, L Zhu, Z Wang, N Hua, S Hu… - Progress in Lipid Research, 2023 - Elsevier
Adipokines play a significant role in cardiometabolic diseases. Asprosin, a newly discovered
adipokine, was first identified as a glucose-raising protein hormone. Asprosin also …

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

K Shabir, JE Brown, I Afzal, S Gharanei… - Cytokine & Growth …, 2021 - Elsevier
White adipose tissue is a dynamic endocrine organ that releases an array of adipokines,
which play a key role in regulating metabolic homeostasis and multiple other physiological …

Asprosin—a fasting-induced, glucogenic, and orexigenic adipokine as a new promising player. Will it be a new factor in the treatment of obesity, diabetes, or infertility …

AI Mazur-Bialy - Nutrients, 2021 - mdpi.com
Asprosin is a recently discovered protein released during fasting conditions mainly by
adipocytes from white adipose tissue. As a glucogenic peptide, it stimulates the release of …

Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue

Y Miao, H Qin, Y Zhong, K Huang… - Journal of …, 2021 - joe.bioscientifica.com
Obesity is an increasingly serious epidemic worldwide characterized by an increase in the
number and size of adipocytes. Adipose tissue maintains the balance between lipid storage …

Asprosin: a novel player in metabolic diseases

M Yuan, W Li, Y Zhu, B Yu, J Wu - Frontiers in endocrinology, 2020 - frontiersin.org
Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of
the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue …

Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride

L Zhang, C Chen, N Zhou, Y Fu, X Cheng - Clinica chimica acta, 2019 - Elsevier
Background Asprosin has been identified as a novel hormone enriched in white adipose
tissue and is pathologically increased in insulin-resistant mice and humans. However …

Asprosin in health and disease, a new glucose sensor with central and peripheral metabolic effects

M Farrag, D Ait Eldjoudi… - Frontiers in …, 2023 - frontiersin.org
Adipose tissue malfunction leads to altered adipokine secretion which might consequently
contribute to an array of metabolic diseases spectrum including obesity, diabetes mellitus …

High serum asprosin levels are associated with presence of metabolic syndrome

T Hong, JY Li, YD Wang, XY Qi, ZZ Liao… - International journal …, 2021 - Wiley Online Library
Objective. Asprosin, a new adipocytokine, has reportedly been associated with glucose
release, dyslipidemia, and insulin resistance (IR). However, the relationship of asprosin with …

Serum concentration of asprosin in new-onset type 2 diabetes

S Naiemian, M Naeemipour, M Zarei… - Diabetology & Metabolic …, 2020 - Springer
Background Asprosin, a newly identified adipokine, is pathologically increased in
individuals with insulin resistance. However, the available evidence on the association of …

The effects of asprosin on exercise-intervention in metabolic diseases

L Liu, Y Liu, M Huang, M Zhang, C Zhu, X Chen… - Frontiers in …, 2022 - frontiersin.org
Fibrillin is the major constituent of extracellular microfibrils, which are distributed throughout
connective tissues. Asprosin is derived from the C-terminal region of the FBN1 gene, which …