The microenvironment within tumors is significantly different from that in normal tissues. A
major difference is seen in the chaotic vasculature of tumors, which results in unbalanced …

A solid tumor presents a unique challenge as a system in which the dynamics of the
relationship between vascularization, the physiological environment and metabolism are …

Metastasis is a multistep process that culminates in the spread of cells from a primary tumor
to a distant site or organs. For tumor cells to be able to metastasize, they have to locally …

A priori knowledge of spatial and temporal changes in partial pressure of oxygen
(oxygenation; pO2) in solid tumors, a key prognostic factor in cancer treatment outcome …

In solid tumors, hypoxia contributes significantly to radiation and chemotherapy resistance
and to poor outcomes. The “gold standard” pO 2 electrode measurements of hypoxia in vivo …

The unique physiological environment of solid tumors, frequently characterized by areas of
poor flow, hypoxia, high lactate and low extracellular pH (pHe), influences vascularization …

This book summarizes current knowledge on blood perfusion and the microenvironment of
human tumors, enabling the reader to gain a deeper insight into the physiological …

Tumors exhibit fluctuations in blood flow that influence oxygen concentrations and
therapeutic resistance. To assist therapeutic planning and improve prognosis, noninvasive …

Tumor oxygenation has long been recognized as a significant factor influencing cancer
therapy. We recently established a novel magnetic resonance in vivo approach to …

Tumor hypoxia results from the negative balance between the oxygen demands of the tissue
and the capacity of the neovasculature to deliver sufficient oxygen. The resulting oxygen …