[HTML][HTML] Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway

MJ Tan, JM Ye, N Turner, C Hohnen-Behrens, CQ Ke… - Chemistry & biology, 2008 - cell.com
Four cucurbitane glycosides, momordicosides Q, R, S, and T, and stereochemistry-
established karaviloside XI, were isolated from the vegetable bitter melon (Momordica …

Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle

X Chen, J Zhuang, J Liu, M Lei, L Ma, J Chen… - Bioorganic & medicinal …, 2011 - Elsevier
AMP-activated kinase (AMPK) as a key controller in the regulation of whole-body energy
homeostasis, plays an important role in protecting the body from metabolic diseases …

Cucurbitane-type triterpenoids in Momordica charantia Linn

SY Lee, SH Eom, YK Kim, NI Park… - Journal of Medicinal …, 2009 - khu.elsevierpure.com
Momordica charantia Linn, belonging to the family of Cucurbitaceae, is a useful medicinal
and vegetable plant for human health and one of the most promising plants for diabetes …

A cell-based screening identifies compounds from the stem of Momordica charantia that overcome insulin resistance and activate AMP-activated protein kinase

HL Cheng, HK Huang, CI Chang, CP Tsai… - Journal of Agricultural …, 2008 - ACS Publications
Treatment of insulin resistance is a critical strategy in the prevention and management of
type 2 diabetes. The crude extracts from all parts of Momordica charantia L. have been …

[HTML][HTML] Momordica charantia L.—Diabetes-Related Bioactivities, Quality Control, and Safety Considerations

SS Çiçek - Frontiers in pharmacology, 2022 - frontiersin.org
Momordica charantia L.(Cucurbitaceae), commonly known as bitter gourd or bitter melon, is
widely cultivated in many tropical and subtropical regions of the world, where its unripe fruits …

Antidiabetic Potentials of Momordica charantia: Multiple Mechanisms Behind the Effects

P Chaturvedi - Journal of medicinal food, 2012 - liebertpub.com
Momordica charantia fruits are used as a vegetable in many countries. From time
immemorial, it has also been used for management of diabetes in the Ayurvedic and …

Momordica charantia constituents and antidiabetic screening of the isolated major compounds

L Harinantenaina, M Tanaka, S Takaoka… - Chemical and …, 2006 - jstage.jst.go.jp
Bioguided fractionation of the methanol extract of Momordica charantia dried gourds led to
the isolation of three new cucurbitane triterpenoids (1—3), together with eight known …

[HTML][HTML] A detailed review on the phytochemical profiles and anti-diabetic mechanisms of Momordica charantia

SF Oyelere, OH Ajayi, TE Ayoade, GBS Pereira… - Heliyon, 2022 - cell.com
Diabetes mellitus is the most well-known endocrine dilemma suffered by hundreds of million
people globally, with an annual mortality of more than one million people. This high mortality …

Differential anti-diabetic effects and mechanism of action of charantin-rich extract of Taiwanese Momordica charantia between type 1 and type 2 diabetic mice

HY Wang, WC Kan, TJ Cheng, SH Yu… - Food and Chemical …, 2014 - Elsevier
Abstract Momordica charantia Linn.(Cucurbitaceae), also called bitter melon, has
traditionally been used as a natural anti-diabetic agent for anti-hyperglycemic activity in …

Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia

PC Hsiao, CC Liaw, SY Hwang, HL Cheng… - Journal of agricultural …, 2013 - ACS Publications
This paper reports that bioassay-guided fractionations of EtOH extract of Momordica
charantia fruits led to the isolation of 15 cucurbitane-type triterpene glycosides including 4 …