Recent studies suggest that CCR5 and its ligands are important regulators for the
development of neuropathic pain and that their modulation can have some beneficial …

Targeting chemokine signaling pathways is crucial in neuropathy development. In this study,
we investigated the influence of chronic administration of maraviroc (CCR5 antagonist) on …

Background: The CCR2/CCL2 system has been identified as a regulator in the
pathogenesis of neuropathy-induced pain. However, CCR2 target validation in analgesia …

The repeated administration of microglial inhibitor (minocycline) and CCR2 antagonist
(RS504393) attenuated the neuropathic pain symptoms in rats following chronic constriction …

Clinical management of neuropathic pain is unsatisfactory, mainly due to its resistance to the
effects of available analgesics, including opioids. Converging evidence indicates the …

Cytokines such as interleukins are known to be involved in the development of neuropathic
pain through activation of neuroglia. However, the role of chemokine (CC motif) ligand 1 …

CCL2 chemokine and its receptor CCR2 may contribute to neuropathic pain development.
We tested the hypothesis that injury to peripheral nerves triggers CCL2 release from …

The CC motif chemokine ligand 5 (CCL5; also known as regulated on activation, normal T
expressed and secreted, or RANTES) is a member of the CC family of chemokines that …

Increasing evidence has indicated that activated glial cells releasing nociceptive factors,
such as interleukins and chemokines, are of key importance for neuropathic pain. Significant …

Lumbar disc herniation (LDH) is a major cause of sciatica, but the underlying mechanisms
are not well understood. Chemokine CCL2 has been implicated to play a vital role in the …