The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Several reviews of inhibitors of topoisomerase II have been published, covering research
before 2018. Therefore, this review is focused primarily on more recent publications with …

The significant role of topoisomerases in the control of DNA chain topology has been
confirmed in numerous research conducted worldwide. The prevalence of these enzymes …

The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously
in all domains of life. The various topoisomerase enzymes perform a wide range of functions …

Topoisomerases are very important enzymes that regulate DNA topology and are vital for
biological actions like DNA replication, transcription, and repair. The emergence and spread …

The topoisomerase enzymes are essential for DNA metabolism, where they act to adjust the
number of supercoils in DNA, a key requirement in the cellular processes of transcription …

This review presents a summary of precinical and clinical data on the topoisomerase I (topo
I) inhibitors that are under clinical development. To date, all of the topo I inhibitors that have …

A large number of secondary metabolites like alkaloids, terpenoids, polyphenols and
quinones are produced by the plants. These metabolites can be utilized as natural …

DNA topoisomerases comprise a major aspect of basic cellular biology and are molecular
targets for a variety of drugs like antibiotics, antibacterials and anticancer drugs. They act by …

CC. Diterpene Terpentecin and Analogs................................................ 413 DD. Lignan
Derivatives............................................................. 414 IV. Dual Topoisomerase I and II …