Deintensification of treatment for human papillomavirus-related oropharyngeal cancer: Current state and future directions

EO Bigelow, TY Seiwert, C Fakhry - Oral oncology, 2020 - Elsevier
Human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has
emerged as a distinct clinical entity of head and neck cancer with expected high survival …

[HTML][HTML] De-escalation studies in HPV-positive oropharyngeal cancer: How should we proceed?

P Golusinski, J Corry, V Vander Poorten, R Simo… - Oral oncology, 2021 - Elsevier
Human papilloma virus (HPV) is a well-established causative factor in a subset of squamous
cell carcinomas of the head and neck (HNSCC). Although HPV can be detected in various …

De-intensification of therapy in human papillomavirus associated oropharyngeal cancer: A systematic review of prospective trials

RR Patel, EB Ludmir, A Augustyn, NG Zaorsky… - Oral oncology, 2020 - Elsevier
Numerous trials have been launched over the prior decade examining the safety and
efficacy of therapy de-escalation in human papillomavirus (HPV)-associated oropharyngeal …

Treatment de‐escalation in HPV‐positive oropharyngeal carcinoma: ongoing trials, critical issues and perspectives

H Mirghani, F Amen, P Blanchard… - … journal of cancer, 2015 - Wiley Online Library
Due to the generally poor prognosis of head and neck squamous cell carcinoma (HNSCC),
treatment has been intensified, these last decades, leading to an increase of serious side …

De-Escalation Strategies for Human Papillomavirus-Associated Oropharyngeal Squamous Cell Carcinoma—Where Are We Now?

JA Silver, S Turkdogan, CF Roy, T Subramaniam… - Current …, 2022 - mdpi.com
The prevalence of oropharyngeal squamous cell carcinoma has been increasing in North
America due to human papillomavirus-associated disease. It is molecularly distinct and …

Current status and future directions of treatment deintensification in human papilloma virus-associated oropharyngeal squamous cell carcinoma

BS Chera, RJ Amdur - Seminars in Radiation Oncology, 2018 - Elsevier
The prevalence of patients with human papilloma virus (HPV)-associated oropharyngeal
squamous cell carcinoma (OPSCC) is rapidly increasing, and it is now well known that these …

[HTML][HTML] What is the future of treatment de-escalation for HPV-positive oropharyngeal cancer? A review of ongoing clinical trials

EA Mensour, S Alam, S Mawani, H Bahig… - Frontiers in …, 2022 - frontiersin.org
Background Human papillomavirus (HPV)-associated oropharyngeal squamous cell
carcinoma (OPSCC) has increased in incidence in recent decades. With higher cure rates in …

[HTML][HTML] De-intensification strategies in HPV-related oropharyngeal squamous cell carcinoma—A narrative review

MP Strohl, KC Wai, PK Ha - Annals of translational medicine, 2020 - ncbi.nlm.nih.gov
Abstract Human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinoma
(OPSCC) is a relatively new clinical entity that is dramatically on the rise globally. HPV+ …

[HTML][HTML] Human papillomavirus–associated oropharyngeal cancer: defining risk groups and clinical trials

A Bhatia, B Burtness - Journal of Clinical Oncology, 2015 - ncbi.nlm.nih.gov
Human papillomavirus–associated oropharynx cancer (HPVA-OPC) is rapidly increasing in
incidence and has unique epidemiologic, molecular, and biologic characteristics. Despite …

Treatment deintensification in human papillomavirus‐positive oropharynx cancer: outcomes from the National Cancer Data Base

S Cheraghlou, PK Yu, MD Otremba, HS Park… - Cancer, 2018 - Wiley Online Library
BACKGROUND The growing epidemic of human papillomavirus‐positive (HPV+)
oropharyngeal cancer and the favorable prognosis of this disease etiology have led to a call …