Background: Idiopathic slow transit constipation is one of the most severe and often
intractable forms of constipation. As motor abnormalities are thought to play an important …

Slow-transit constipation is usually considered a colonic motor disorder. However, there is
some evidence that abnormalities may be present in locations other than the colon. In …

Constipation has been traditionally viewed and classified as a functional or idiopathic
disorder. However, evidence has been accumulating that suggests how constipation might …

PURPOSE: Several alterations of the enteric nervous system have been described as an
underlying neuropathologic correlate in patients with idiopathic slow-transit constipation. To …

Patients suffering from idiopathic slowtransit chronic constipation have a delayed colonic
transit referable to a decrease or loss of propagating contractions. Myogenic andlor neural …

PURPOSE: The aim of this study was to investigate neuropathologic changes in the colonic
wall of patients with slow transit constipation using monoclonal antibodies raised against …

Abnormalities of the enteric nervous system are thought to explain the pathophysiology of
motility disorders. Our aim was to determine if particular classes of enteric neurons are …

Slow transit constipation has been traditionally considered and classified as a functional
disorder. However, clinical and manometric evidence has been accumulating that suggests …

In recent years, the improvement of technology and the increase in knowledge have shifted
several strongly held paradigms. This is particularly true in gastroenterology, and specifically …

Background & Aims: A variety of gastrointestinal motility disorders have been attributed to
alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This …