細菌感染症におけるRNA の機能解明と抗菌治療への応用

氣駕恒太朗 - 日本細菌学雑誌, 2022 - jstage.jst.go.jp
抄録 セントラルドグマ (DNA から RNA が転写されて, タンパク質ができる) という分子生物学の
中心的な概念において,「RNA は DNA からタンパク質を合成するための遺伝情報の仲介役にすぎ …

RNA functions in bacterial infections and its application to antimicrobial therapy

K Kiga - Nihon Saikingaku zasshi. Japanese Journal of …, 2022 - europepmc.org
In the concept of central dogma (RNA is transcribed from DNA to produce proteins), RNA
was thought to be merely an intermediary for genetic information to synthesize proteins from …

[PDF][PDF] Small RNAs of pathogenic bacteria: not small enough to be overlooked for therapeutics

VR Iyer, R Sharma, R Pathania… - Molecular and Cellular …, 2012 - mcpharmacol.com
The discovery of non-coding small RNA and miRNA has increased the understanding of
gene regulation in all forms of life. Even though majority of research in the non-coding RNA …

Physiological roles of small RNA molecules

C Michaux, N Verneuil, A Hartke, JC Giard - Microbiology, 2014 - microbiologyresearch.org
Unlike proteins, RNA molecules have emerged lately as key players in regulation in
bacteria. Most reviews hitherto focused on the experimental and/or in silico methods used to …

[HTML][HTML] RNA techniques for bacteria

E Charpentier, R Schroeder - Current opinion in microbiology, 2007 - ncbi.nlm.nih.gov
Bacteria were the first source of the major discoveries that changed our perception of RNA.
In 1982 in the laboratory of Sidney Altman, it was found that the catalytic component of …

[HTML][HTML] Control of the gut microbiome by fecal microRNA

S Liu, HL Weiner - Microbial Cell, 2016 - ncbi.nlm.nih.gov
Since their discovery in the early 90s, microRNAs (miRNAs), small non-coding RNAs, have
mainly been associated with posttranscriptional regulation of gene expression on a cell …

Micro rna s and bacterial infection

C Staedel, F Darfeuille - Cellular microbiology, 2013 - Wiley Online Library
Micro RNA s, small non‐coding RNAs expressed by eukaryotic cells, play pivotal roles in
shaping cell differentiation and organism development. Deregulated micro RNA expression …

The mammalian microRNA response to bacterial infections

A Eulalio, L Schulte, J Vogel - RNA biology, 2012 - Taylor & Francis
MicroRNAs are small RNAs that post-transcriptionally regulate eukaryotic gene expression.
In addition to their involvement in a wide range of physiological and pathological processes …

[PDF][PDF] 腸内細菌による腸管粘膜免疫の調節におけるmicroRNA の役割に関する研究[全文の要約]

逢坂文那 - 2021 - eprints.lib.hokudai.ac.jp
哺乳類の腸管には, 1,000 種類を超える細菌種が総数で約 100 兆個生息し, 多様な生態系
(腸内細菌叢) を形成している (Bäckhed et al. 2005). 腸内細菌は主に 4 つの門 (Firmicutes …

The infinite possibilities of RNA therapeutics

EC Mollocana-Lara, M Ni, SN Agathos… - Journal of Industrial …, 2021 - academic.oup.com
Although the study of ribonucleic acid (RNA) therapeutics started decades ago, for many
years, this field of research was overshadowed by the growing interest in DNA-based …