[HTML][HTML] Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes …

YON Lopez, A Iliuk, A Casu, A Parikh, JS Smith… - Diabetes Research and …, 2023 - Elsevier
Recent studies suggest that extracellular vesicles (EVs) play a role in the pathogenesis of
SARS-CoV-2 infection and the severity of COVID-19. However, their role in the interaction …

Type-2 diabetes, a co-morbidity in Covid-19: does insulin signaling matter?

D Mishra, CS Dey - Biochemical Society Transactions, 2021 - portlandpress.com
Type-2 Diabetes is associated with one of the co-morbidities due to SARS-Coronavirus 2
(SARS-Cov2) infection. Clinical studies show out of control glucose levels in SARS-Cov2 …

[HTML][HTML] Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory …

T Kawasaki, Y Takeda, R Edahiro, Y Shirai… - Inflammation and …, 2022 - Springer
Background The coronavirus disease 2019 (COVID-19) pandemic is widespread; however,
accurate predictors of refractory cases have not yet been established. Circulating …

[HTML][HTML] Prediction of post-acute-sequelae of COVID-19 by cargo protein biomarkers of blood total extracellular vesicles in acute COVID-19

EJ Goetzl, PJ Yao, D Kapogiannis - The American Journal of Medicine, 2023 - Elsevier
Background SARS-CoV-2 invades mitochondria of infected cells resulting in disordered
metabolism, mitophagy, and abnormal levels of mitochondrial proteins in extracellular …

CD66b+/CD68+ circulating extracellular vesicles, lactate dehydrogenase and neutrophil‐to‐lymphocyte ratio can differentiate coronavirus disease 2019 severity …

R Suades, MF Greco, P Prieto, T Padró… - Journal of …, 2024 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) has been a major public health burden. We
hypothesised that circulating extracellular vesicles (cEVs), key players in health and …

[HTML][HTML] Proteomic profile of procoagulant extracellular vesicles reflects complement system activation and platelet hyperreactivity of patients with severe COVID-19

ECS Moraes, R Martins-Gonçalves, LR Silva… - Frontiers in Cellular …, 2022 - frontiersin.org
Background Extracellular vesicles (EVs) are a valuable source of biomarkers and display
the pathophysiological status of various diseases. In COVID-19, EVs have been explored in …

[HTML][HTML] Proteomic profiling of single extracellular vesicles reveals colocalization of SARS-CoV-2 with a CD81/integrin-rich EV subpopulation in sputum from COVID …

R Sun, Y Cai, Y Zhou, G Bai, A Zhu, P Kong… - Frontiers in …, 2023 - frontiersin.org
Background The global outbreak of COVID-19, and the limited availability of clinical
treatments, forced researchers around the world to search for the pathogenesis and …

[HTML][HTML] The potential role of extracellular vesicles in COVID-19 associated endothelial injury and pro-inflammation

B Krishnamachary, C Cook, L Spikes, P Chalise… - medRxiv, 2020 - ncbi.nlm.nih.gov
COVID-19 infection caused by the novel severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) has resulted in a global pandemic with the number of deaths growing …

Proteomic analysis identifies prolonged disturbances in pathways related to cholesterol metabolism and myocardium function in the COVID-19 recovery stage

Y Chen, H Yao, N Zhang, J Wu, S Gao… - Journal of Proteome …, 2021 - ACS Publications
The COVID-19 pandemic has become a worldwide health crisis. So far, most studies have
focused on the epidemiology and pathogenesis of this infectious disease. Little attention has …

[HTML][HTML] Circulating exosomes are strongly involved in SARS-CoV-2 infection

E Barberis, VV Vanella, M Falasca… - Frontiers in molecular …, 2021 - frontiersin.org
Knowledge of the host response to the novel coronavirus SARS-CoV-2 remains limited,
hindering the understanding of COVID-19 pathogenesis and the development of therapeutic …