[PDF][PDF] Effects of transcription elongation rate and Xrn2 exonuclease activity on RNA polymerase II termination suggest widespread kinetic competition
The torpedo model of transcription termination asserts that the exonuclease Xrn2 attacks the
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …
5′ PO 4-end exposed by nascent RNA cleavage and chases down the RNA polymerase …
[PDF][PDF] mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription
We report a function of human mRNA decapping factors in control of transcription by RNA
polymerase II. Decapping proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 …
polymerase II. Decapping proteins Edc3, Dcp1a, and Dcp2 and the termination factor TTF2 …
Pause sites promote transcriptional termination of mammalian RNA polymerase II
N Gromak, S West, NJ Proudfoot - Molecular and cellular biology, 2006 - Taylor & Francis
Polymerase II (Pol II) transcriptional termination depends on two independent genetic
elements: poly (A) signals and downstream terminator sequences. The latter may either …
elements: poly (A) signals and downstream terminator sequences. The latter may either …
Human 5′→ 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
S West, N Gromak, NJ Proudfoot - Nature, 2004 - nature.com
Eukaryotic protein-encoding genes possess poly (A) signals that define the end of the
messenger RNA and mediate downstream transcriptional termination by RNA polymerase II …
messenger RNA and mediate downstream transcriptional termination by RNA polymerase II …
The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3′ processing and transcription termination
S Kaneko, O Rozenblatt-Rosen… - Genes & …, 2007 - genesdev.cshlp.org
Termination of RNA polymerase II transcription frequently requires a poly (A) signal and
cleavage/polyadenylation factors. Recent work has shown that degradation of the …
cleavage/polyadenylation factors. Recent work has shown that degradation of the …
[PDF][PDF] Genome-wide analysis of RNA polymerase II termination at protein-coding genes
At the end of protein-coding genes, RNA polymerase (Pol) II undergoes a concerted
transition that involves 3′-processing of the pre-mRNA and transcription termination. Here …
transition that involves 3′-processing of the pre-mRNA and transcription termination. Here …
The role of Rat1 in coupling mRNA 3′-end processing to transcription termination: implications for a unified allosteric–torpedo model
The torpedo model of transcription termination by RNA polymerase II proposes that a 5′–
3′ RNA exonuclease enters at the poly (A) cleavage site, degrades the nascent RNA, and …
3′ RNA exonuclease enters at the poly (A) cleavage site, degrades the nascent RNA, and …
Mechanism of eukaryotic RNA polymerase III transcription termination
Gene expression in organisms involves many factors and is tightly controlled. Although
much is known about the initial phase of transcription by RNA polymerase III (Pol III), the …
much is known about the initial phase of transcription by RNA polymerase III (Pol III), the …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
Transcription termination by nuclear RNA polymerases
P Richard, JL Manley - Genes & development, 2009 - genesdev.cshlp.org
Gene transcription in the cell nucleus is a complex and highly regulated process.
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …
Transcription in eukaryotes requires three distinct RNA polymerases, each of which employs …