[HTML][HTML] Silibinin triggers the mitochondrial pathway of apoptosis in human Oral squamous carcinoma cells

RM Iyengar, E Devaraj - Asian Pacific journal of cancer prevention …, 2020 - ncbi.nlm.nih.gov
Background: Silibinin, a natural polyphenolic flavonoid present in seed extracts of milk
thistle (Silybum marianum). It has been shown to interact with various cancer-related cell …

[HTML][HTML] Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways

MB Pirouzpanah, M Sabzichi… - Asian Pacific journal …, 2015 - koreascience.kr
Nowadays herbal-derived medicines are attracting attention as new sources of drugs with
few side effects. Silibinin is a flavonoid compound with chemotheraputic effects on different …

Comparative evaluation of silibinin effects on cell cycling and apoptosis in human breast cancer MCF-7 and T47D cell lines

Z Jahanafrooz, N Motameh… - Asian Pacific Journal of …, 2016 - journal.waocp.org
Silibinin is a natural polyphenol with high antioxidant and anticancer properties. In this
study, its influence on two of the most commonly employed human breast cancer cell lines …

[PDF][PDF] Silibinin promotes the apoptosis of gastric cancer BGC823 cells through caspase pathway

R Li, J Yu, C Wang - J BUON, 2017 - jbuon.com
Purpose: To investigate the effects of silibinin, a natural compound, on the proliferation and
apoptosis of BGC-823 gastric cancer cell line and to figure out the relevant pathways …

[HTML][HTML] Adjuvant therapy with silibinin improves the efficacy of paclitaxel and cisplatin in MCF-7 breast cancer cells

H Chavoshi, V Vahedian, S Saghaei… - Asian Pacific journal …, 2017 - ncbi.nlm.nih.gov
Herbal-derived medicines have introduced as sources of novel drugs due to minimum
systemic side effects. Silibinin as a flavonoid compound has showed with effective …

Silibinin induced the apoptosis of Hep-2 cells via oxidative stress and down-regulating survivin expression

X Yang, X Li, L An, B Bai, J Chen - European Archives of Oto-Rhino …, 2013 - Springer
Silibinin is an anticancer and chemopreventive natural compound, which is extracted from
milk thistle (Silybum marianum). It is reported that silibinin has anticancer efficacy in many …

The effects of silibinin on the induction of apoptosis and inhibition of cell growth in MCF-7 breast cancer cell line

M Pirouzpanah, S Pirouzpanah, M Sabzichi… - Iranian Journal of …, 2015 - nsft.sbmu.ac.ir
Background and Objectives: Breast cancer is one of the most common leading causes of
cancer–related mortality in women. Silibinin, a natural flavonolignane and the main …

Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells

J Ham, W Lim, FW Bazer, G Song - Journal of cellular …, 2018 - Wiley Online Library
Silibinin is a flavonolignan extracted from seeds of milk thistles. Traditionally, it has been
used as a therapeutic agent for liver disorders, and now it is well‐known for its anti‐cancer …

The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells

D Bayram, ES Çetin, M Kara… - Human & …, 2017 - journals.sagepub.com
Background: Silibinin is a bioactive flavonolignan extracted from milk thistle, known as
Silybum marianum. Silibinin exerts strong antiproliferative, proapoptotic, and anti …

Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis

SH Kim, KY Kim, SN Yu, YK Seo, SS Chun, HS Yu… - BMC cancer, 2016 - Springer
Background Silibinin, a biologically active compound of milk thistle, has chemopreventive
effects on cancer cell lines. Recently it was reported that silibinin inhibited tumor growth …