Background A revolutionary diversion from classical vaccinology to reverse vaccinology
approach has been observed in the last decade. The ever-increasing genomic and …

Bacterial infectious diseases remain the single most important threat to health worldwide.
Although conventional vaccinology approaches were successful in conferring protection …

In the post-genomic era, strategies of vaccine development have progressed dramatically
from traditional Pasteur's principles of isolating, inactivating and injecting the causative …

Background With advances in reverse vaccinology approaches, a progressive improvement
has been observed in the prediction of putative vaccine candidates. Reverse vaccinology …

Whole-genome sequencing of bacteria and advances in bioinformatics have revolutionized
the vaccinology field, leading to the identification of potential vaccine candidates without the …

During the past decade, sequencing of the entire genome of pathogenic bacteria has
become a widely used practice in microbiology research. More recently, sequence data from …

Reverse vaccinology (RV) was described at its inception in 2000 as an in silico process that
starts from the genomic sequence of the pathogen and ends with a list of potential protein …

Highlights•Wealth of genome data are making pan-genome analysis increasingly
possible.•Pan-genome analysis is an effective approach to understand pathogenic …

Clin Microbiol Infect 2012; 18 (Suppl. 5): 109–116 Abstract Vaccines have a significant
impact on public health, and vaccinology in the era of genomics is taking advantage of new …

Vaccination is one of the most effective tools for the prevention of infectious diseases. The
availability of complete genome sequences, together with the progression of high …