Treatment targets in renal fibrosis

P Boor, K Šebeková, T Ostendorf… - Nephrology Dialysis …, 2007 - academic.oup.com
Renal fibrosis is the principal process underlying the progression of chronic kidney disease
(CKD) to endstage renal disease (ESRD). It is a relatively uniform response involving …

Novel insights into renal fibrosis

F Eitner, J Floege - Current opinion in nephrology and …, 2003 - journals.lww.com
Novel insights into renal fibrosis : Current Opinion in Nephrology and Hypertension Novel
insights into renal fibrosis : Current Opinion in Nephrology and Hypertension Log in or Register …

Renal fibrosis: insights into pathogenesis and treatment

AM El Nahas, EC Muchaneta-Kubara… - The international journal …, 1997 - Elsevier
The progression of chronic renal failure is characterised histologically by
glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. Recent research has …

Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Mechanisms of renal fibrosis

BD Humphreys - Annual review of physiology, 2018 - annualreviews.org
Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

[HTML][HTML] Renal fibrosis: new insights into the pathogenesis and therapeutics

Y Liu - Kidney international, 2006 - Elsevier
Renal fibrosis is the inevitable consequence of an excessive accumulation of extracellular
matrix that occurs in virtually every type of chronic kidney disease. The pathogenesis of …

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

SMW Yu, JV Bonventre - Current opinion in nephrology and …, 2020 - journals.lww.com
Acute kidney injury and maladaptive tubular repair leading t... : Current Opinion in Nephrology
and Hypertension Acute kidney injury and maladaptive tubular repair leading to renal fibrosis …

What can target kidney fibrosis?

IA Leaf, JS Duffield - Nephrology Dialysis Transplantation, 2017 - academic.oup.com
Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

[HTML][HTML] Overview of the cellular and molecular basis of kidney fibrosis

AA Eddy - Kidney international supplements, 2014 - Elsevier
The common pathogenetic pathway of progressive injury in patients with chronic kidney
disease (CKD) is epitomized as normal kidney parenchymal destruction due to scarring …

[引用][C] On the progression of chronic renal disease

F Strutz, GA Müller - Nephron, 1995 - karger.com
Chronic renal failure is defined by a persistent reduction in the glomerular filtration rate
(GFR) and a probable pro gression to end-stage renal disease [1], According to the Registry …