Structure, function, and inhibition of chemokines

EJ Fernandez, E Lolis - Annual review of pharmacology and …, 2002 - annualreviews.org
Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

Chemokine: receptor structure, interactions, and antagonism

SJ Allen, SE Crown, TM Handel - Annu. Rev. Immunol., 2007 - annualreviews.org
Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

Touch of chemokines

X Blanchet, M Langer, C Weber, RR Koenen… - Frontiers in …, 2012 - frontiersin.org
Chemoattractant cytokines or chemokines constitute a family of structurally related proteins
found in vertebrates, bacteria, or viruses. So far, 48 chemokine genes have been identified …

Chemokine blockers–therapeutics in the making?

TNC Wells, CA Power, JP Shaw… - Trends in pharmacological …, 2006 - cell.com
Chemokines are a family of small chemoattractant cytokines that have an important role in
controlling leukocyte migration. The finding that some chemokines and their receptors are …

Chemokine receptors and their role in inflammation and infectious diseases

C Murdoch, A Finn - Blood, The Journal of the American Society …, 2000 - ashpublications.org
Chemokines are small peptides that are potent activators and chemoattractants for leukocyte
subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7 …

The biology of chemokines and their receptors

D Rossi, A Zlotnik - Annual review of immunology, 2000 - annualreviews.org
During the last five years, the development of bioinformatics and EST databases has been
primarily responsible for the identification of many new chemokines and chemokine …

Recent advances in chemokines and chemokine receptors

JA Hedrick, J Morales, A Zlotnik - Critical Reviews™ in …, 1999 - dl.begellhouse.com
Chemokines are a superfamily of small cytokine-like molecules which have been described
primarily on the basis of their ability to mediate the migration of verious cell types …

Chemokines and their receptors: drug targets in immunity and inflammation

A Viola, AD Luster - Annu. Rev. Pharmacol. Toxicol., 2008 - annualreviews.org
The chemokine system coordinates leukocyte migration in immunity and inflammation and is
implicated in the pathogenesis of many human diseases. Although several successful …

Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses

RP Bhusal, SR Foster, MJ Stone - Protein Science, 2020 - Wiley Online Library
In response to infection or injury, the body mounts an inflammatory immune response in
order to neutralize pathogens and promote tissue repair. The key effector cells for these …

Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors

M Szpakowska, V Fievez, K Arumugan… - Biochemical …, 2012 - Elsevier
Chemokines and their receptors play fundamental roles in many physiological and
pathological processes such as leukocyte trafficking, inflammation, cancer and HIV-1 …