Role of MGMT in tumor development, progression, diagnosis, treatment and prognosis
S Sharma, F Salehi, BW Scheithauer… - Anticancer …, 2009 - ar.iiarjournals.org
O6-Methylguanine-DNA-methyltransferase (MGMT) is a unique protein, which both repairs
O6-alkylguanine lesions stoichiometrically without a multi-enzymatic pathway and self …
O6-alkylguanine lesions stoichiometrically without a multi-enzymatic pathway and self …
O6-Methylguanine-DNA methyltransferase (MGMT) in normal tissues and tumors: enzyme activity, promoter methylation and immunohistochemistry
M Christmann, B Verbeek, WP Roos, B Kaina - Biochimica et Biophysica …, 2011 - Elsevier
O6-Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-
mutagenic, pre-carcinogenic and pre-toxic DNA damage O6-methylguanine. It also repairs …
mutagenic, pre-carcinogenic and pre-toxic DNA damage O6-methylguanine. It also repairs …
[HTML][HTML] O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
W Yu, L Zhang, Q Wei, A Shao - Frontiers in oncology, 2020 - frontiersin.org
Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT …
Resistance to alkylating agents via direct DNA repair by O (6)-methylguanine
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
methyltransferase (MGMT) remains a significant barrier to the successful treatment of …
Targeted modulation of MGMT: clinical implications
L Liu, SL Gerson - Clinical cancer research, 2006 - AACR
Abstract O6-Methylguanine DNA methyltransferase (MGMT) has been studied for> 20 years
as a gene that is associated with the mutagenicity and cytotoxicity induced by either …
as a gene that is associated with the mutagenicity and cytotoxicity induced by either …
O6-Methylguanine-DNA methyltransferase in glioma therapy: Promise and problems
JR Silber, MS Bobola, A Blank… - Biochimica et Biophysica …, 2012 - Elsevier
Gliomas are the most frequent adult primary brain tumor, and are invariably fatal. The most
common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the US …
common diagnosis glioblastoma multiforme (GBM) afflicts 12,500 new patients in the US …
Post-transcriptional regulation of O 6-methylguanine-DNA methyltransferase MGMT in glioblastomas
V Ramakrishnan, D Kushwaha, DC Koay… - Cancer …, 2012 - content.iospress.com
Background: The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT)
confers therapeutic resistance to DNA alkylating agents, including temozolomide. It is largely …
confers therapeutic resistance to DNA alkylating agents, including temozolomide. It is largely …
Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma
G Cabrini, E Fabbri, C Lo Nigro… - International …, 2015 - spandidos-publications.com
Abstract O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed
nuclear protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the …
nuclear protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the …
Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors
CB Jackson, SI Noorbakhsh, RK Sundaram… - Cancer research, 2019 - AACR
Abstract O6-methylguanine-DNA methyltransferase (MGMT) is an enzyme that removes
alkyl groups at the O6-position of guanine in DNA. MGMT expression is reduced or absent in …
alkyl groups at the O6-position of guanine in DNA. MGMT expression is reduced or absent in …
MGMT in primary and recurrent human glioblastomas after radiation and chemotherapy and comparison with p53 status and clinical outcome
D Wiewrodt, G Nagel, N Dreimüller… - … journal of cancer, 2008 - Wiley Online Library
The DNA repair protein O6‐methylguanine‐DNA methyltransferase (MGMT) plays a pivotal
role in alkylating drug resistance. Here, we determined MGMT activity in primary and …
role in alkylating drug resistance. Here, we determined MGMT activity in primary and …