The neurotrophins mediate diverse actions in the developing peripheral and central nervous
systems. They are initially synthesized as precursor forms, or proneurotrophins, that are …

Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …

Neurotrophins have diverse functions in the CNS. Initially synthesized as precursors
(proneurotrophins), they are cleaved to produce mature proteins, which promote neuronal …

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

Neurotrophins provide trophic and tropic support for different neuronal subpopulations in the
developing and adult nervous systems. Expression of the neurotrophins and their receptors …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Neurotrophins: Neurotrophins are peptides or proteins that are known to regulate neuronal
viability, development, and function. Beyond synaptic plasticity, neurotrophins protect …

The temporally specific nature of neurotrophic factor-induced responses is a general feature
of mammalian nervous system development, the mechanisms of which remain to be …

There is growing evidence that reduced neurotrophic support is a significant factor in the
pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's …

Neurotrophins and synaptic activity work in conjunction during the process of synaptic
plasticity. Both are required to stabilize new synaptic structures and the loss of either can …